Abstract
Objective: The purpose of this study is to investigate the physiological pulmonary perfusion pattern in different respiratory phases by calculating the normalized volume center of perfusion intensity.Methods: Four nonsmoking volunteers underwent single photon emission computed tomography (SPECT) of maximum inspiration and expiration after the injection of Tc-99m-MAA in each respiratory phase at a week’s interval. Quantitative analysis by calculating the normalized volume center of perfusion intensity was performed.Results: Quantitative measurement of the normalized volume center of perfusion intensity showed, that the percentage averages of ventrodorsal (Y) shift in maximum respiration were 16% (left) and 15% (right) in the upper part, 15% (left) and 14% (right) in the middle part, 17% (left) and 18% (right) in the lower part, 18% (left) and 16% (right) in each total lung. These readings indicated that the normalized center of pulmonary perfusion activity at maximum expiration moved in the ventral direction in contrast to that at maximum inspiration. In horizontal (X) and craniocaudal (Z) directions, the shift in the normalized center of pulmonary perfusion activity at maximum expiration indicated no agreement in movement direction.Conclusion: The normalized center of the pulmonary perfusion activity in maximum expiration moved in the ventral direction compared to that in maximum inspiration. This phenomenon might be caused by the increase in physiological intrathoracic pressure and by a definite reserve of pulmonary perfusion.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Frazer RG.The Pulmonary Vascular System. W.B. Saunders Co., 1970.
Ross DJ, Pearl WU, Zab M. Assessment of postural differences in regional pulmonary perfusion in man by single photon emission computerized tomography.Clin Sci 1997; 92: 81–85.
Anthonisen NR, Milic-Emili J. Distribution of pulmonary perfusion in erect man.J Appl Physiol 1966; 21: 760–766.
Almquist HM, Palmer J, Jonson B, Wollmer P. Pulmonary perfusion and density gradients in healthy volunteers.J Nucl Med 1997; 38: 962–966.
Hatkim TS, Lisboina R, Dean GW. Gravity-independent enequality in pulmonary blood flow in humans.J Appl Physiol 1987; 64: 1114–1121.
Hatkim TS, Dean GW, Lisboina R. Effect of body posture on spatial distribution of pulmonary blood flow.J Appl Physiol 1988; 64: 1160–1170.
West JB, Dollery CT, Naimark A. Distribution of inspired air, distribution of blood flow in isolated lung, relation to vascular and alveolar pressures.J Appl Physiol 1964; 19: 713–724.
Kosuda S, Kobayashi H, Kusano S. Change in regional pulmonary perfusion as a result of posture and lung volume assessed using technetium-99m macroaggregated albumin SPET.Eur J Nucl Med 2000, 27: 529–535.
PIOPED investigators. Value of the ventilation/perfusion scan in acute pulmonary embolism: results of the prospective investigation of pulmonary embolism diagnosis (PIOPED).JAMA 1990; 263: 2753–2759.
Gottschalk A, Juni JE, Sostman HD., Coleman RE, Thrall J, McKusick KA, et al. Ventilation-perfusion scintigraphy in the PIOPED study. Part I. Data collection and tabulation.J Nucl Med 1993; 34: 1109–1118.
Gottschalk A, Sostman HD, Coleman RE, Juni JE, Thrall J, McKusick KA, et al. Ventilation-perfusion scintigraphy in the PIOPED study. Part II. Evaluation of the scintigraphic criterial and interpretations.J Nucl Med 34: 1119–1126.
Worsley DF, Alan A. Comprehensive analysis of the results of the PIOPED study.J Nucl Med 1995; 36: 2380–2387.
Julius AJ, Jong D, Deutecom H, Heidendal GA, Otter G, Krester AD. The value of Tc-99m macroaggregated albumin lung perfusion scanning in the prediction of postpneumonectomy function and pulmonary artery pressure.Scand J Thor Cardiovasc Surg 1987; 21: 81–85.
Hardoff P, Steinmets AP, Krausz Y. The prognostic value of perfusion lung scintigraphy in patients who underwent single lung transplantation for emphysema and pulmonary fibrosis.J Nucl Med 2000; 41: 1771–1776.
Hirose Y, Imaeda T, Doi H, Kokubo M, Sakai S, Hirose H. Lung perfusion SPECT in predicting postoperative pulmonary function in lung cancer.Ann Nucl Med 1993; 7: 123–126
Magnussen JS, Chicco P, Palmar AW, Mackey DW, Magee M, Murray IPC. Enhanced accuracy and reproducibility in reporting of lung scintigrams by a segmental reference charts.J Nucl Med 1998; 39: 1095–1099.
Vanniren E, Tenhunen-Eskelinen M, Mussalo H, Toyry J, Laitinen T, Ahonen E, et al. Are three-dimensional surface shaded SPET images better than planar and coronal SPET in the assessment of regional pulmonary perfusion?Nucl Med Commun 1997; 18: 423–430.
Votin DM, Harmognies DH, Duvivier DH, Vandenput SN, Art T, Lekeux PM. Pulmonary perfusion, redistribution in exercised horses. Proceedings of the 47th annual meetings.J Nucl Med 2000; 41 (Suppl): 325p.
Suga K. Respiratory nuclear medicine for general radiologist.Nippon Acta Radiologica 2000; 60: 684–690.
Berne RM, Levy MN.Physiology. Third edition, The cardiovascular system. Respiratory activity. St. Louis; Mosby, 1993; 507–508.
Jardin F, Brun-Ney D, Cazaux P, Dubourg O, Hardy A, Bourdarias JP. Relation between transpulmonary pressure and right ventricular pressure change during respiratory support.Cathet Cardiovasc Diagn 1989; 16: 215–220.
Conti F, Bertoli L, Rizzato G, Stefanoni G, Biasi G. Correlation between tracheal pressure and pulmonary artery pressure in healthy dogs.J Cardiovasc Surg 1977; 18: 427–434.
Rutici A, Grossoni M, Ukmar G, Tommasini R, Morpurgo M. Which moments in the respiratory cycle have the most influence on right ventricular dynamics?G Ital Cardiol 1988; 18: 1018–1024.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yoshida, S., Wu, D., Fukumoto, M. et al. Quantitative study of the difference in pulmonary perfusion in different respiratory phases in healthy volunteers. Ann Nucl Med 16, 533–539 (2002). https://doi.org/10.1007/BF02988630
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02988630