Abstract
Purpose: Esophageal motility was assessed in patients with systemic selerosis (SSc) by scintigraphy and compared with (i) extent of scleroderma, (ii) duration of disease, (iii) index of antitopoisomerase I antibody (topo I), and (iv) pulmonary involvement.Methods: A multiple-swallow test was performed in 47 patients with SSc in the supine position with99mTc-DTPA. A region of interest on the entire esophagus was defined and the retention ratio (RR) was calculated from a time-activity curve.Results: Patients with diffuse scleroderma had higher RRs than those with limited scleroderma (48.8% vs. 30.0%; p<0.05). There was no correlation between the RRs and the duration of disease. Patients with positive topo I had higher RRs than those who were negative (53.8% vs. 29.7%; p<0.05). Patients with reduced % diffusion capacity for carbon monoxide (%DLCO) had higher RRs thans those with normal %DLCO (40.5% vs. 19.6%; p=0.03). Patients with reduced % vital capacity (%VC) had higher RRs than those with normal % VC (54.6% vs. 25.0%; p<0.005). Patients with pulmonary fibrosis had higher RRs than those who were negative (58.5% vs. 20.3%; p<0.00005).Conclusion: Esophageal dysfunction in patients with SSc showed a correlation with the extent of scleroderma, positive topo I, and pulmonary involvement. The RR can be an objective clinical marker for the severity of organ fibrosis.
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Kinuya, K., Nakajima, K., Kinuya, S. et al. Esophageal hypomotility in systemie sclerosis: Close relationship with pulmonary involvement. Ann Nucl Med 15, 97–101 (2001). https://doi.org/10.1007/BF02988598
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DOI: https://doi.org/10.1007/BF02988598