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Intrasubject correlation between static sean and distribution volume images for [11C]flumazenil PET

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Abstract

Accumulation of [11C]flumazenil (FMZ) reflects central nervous system benzodiazepine receptor (BZR). We searched for the optimal time for a static PET scan with FMZ as semi-quantitative imaging of BZR distribution. In 10 normal subjects, a dynamic series of decay-corrected PET scans was performed for 60 minutes, and the arterial blood was sampled during the scan to measure radioactivity and labeled metabolites. We generated 13 kinds of “static scan” images from the dynamic scan in each subject, and analyzed the pixel correlation for these images versus distribution volume (DV) images. We also analyzed the time for the [11C]FMZ in plasma and tissue to reach the equilibrium. The intra-subject pixel correlation demonstrated that the “static scan” images for the period centering around 30 minutes post-injection had the strongest linear correlation with the DV image. The ratio of radioactivity in the cortex to that in the plasma reached a peak at 40 minutes after injection. Considering the physical decay and patient burden, we conclude that the decay corrected static scan for [11C]FMZ PET as semi-quantitative imaging of BZR distribution is to be optimally acquired from 20 to 40 minutes after injection.

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Authors and Affiliations

  1. Second Department of Internal Medicine, Nippon Medical School, Tokyo, Japan

    Masahiro Mishina, Masashi Ohyama, Shin Kitamura & Yasuo Katayama

  2. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1-1 Naka-cho, Itabashi-ku, 173-0022, Tokyo, Japan

    Hinako Toyama, Masashi Ohyama, Tadashi Nariai, Kenji Ishii, Kei-ichi Oda & Toru Sasaki

  3. Medical Information Processing Office, Research Center of Charged Particle Therapy, National Institute of Radiological Sciences, Japan

    Masahiro Mishina, Michio Senda, Yuichi Kimura, Hinako Toyama & Kiishi Ishiwata

  4. Department of Neurosurgery, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan

    Tadashi Nariai

Authors
  1. Masahiro Mishina
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  2. Michio Senda
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  3. Yuichi Kimura
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  4. Hinako Toyama
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  5. Kiishi Ishiwata
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  6. Masashi Ohyama
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  7. Tadashi Nariai
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  8. Kenji Ishii
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  9. Kei-ichi Oda
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  10. Toru Sasaki
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  11. Shin Kitamura
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  12. Yasuo Katayama
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Correspondence to Masahiro Mishina.

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Mishina, M., Senda, M., Kimura, Y. et al. Intrasubject correlation between static sean and distribution volume images for [11C]flumazenil PET. Ann Nucl Med 14, 193–198 (2000). https://doi.org/10.1007/BF02987859

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  • DOI: https://doi.org/10.1007/BF02987859

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