Abstract
Colonic adenomas constitute 70-80% of all colorectal polyps, and their clinical significance relates primarily to their relationship with colorectal cancer. The malignant potential of the polyps detected by FDG-PET is unknown, as not all the colonic lesions identified by FDG-PET represent colorectal malignancies. The purpose of this study was to investigate the rate of FDG-PET positivity within colonie villous adenomas. A pathology database search was performed to identify all patients diagnosed with colonic villous adenoma between June 1, 1996 and December 1, 2000. Patients with a pathologic diagnosis of colonic villous adenoma and who also had a FDG-PET study up to 1 month before colonoscopy were included in this study. FDG-PET findings were compared with pathological features. Of more than 4,000 patients, six patients were diagnosed with colonic adenoma on subsequent colonoscopy following FDG-PET study. Based on the pathological findings, these 6 patients had a total of 2 villous and 9 tubulovillous adenomas. Five of the 6 patients showed foci of increased FDG uptake in the region of the colon that corresponded to the villous adenoma(s) detected on colonoscopy, which accounted for a true-positive rate of 83.3% (5/6 subjects). Focal lesions in the colon seen on FDG-PET examinations need to be investigated further, even though some of these will prove to be villous adenomas rather than colorectal carcinomas. Future studies in a larger number of patients are needed to evaluate the relationship of histopathological features of colonie polyps and detectability of these lesions by FDG-PET.
References
Ackroyd FW, Hedberg SE. Colonic polyps.Annu Rev Med 1985; 36: 619–625.
Drenth JP, Nagengast FM, Oyen WJ. Evaluation of (pre-) malignant colonie abnormalities: endoscopie validation of FDG-PET findings:EurJ Nucl Med 2001; 28: 1766–1769.
Yasuda S, Fuji H, Nakahara T, et al.18F-FDG PET detection of colonic adenomas.J Nucl Med 2001; 42: 989–992.
Tatlidil R, Jadvar H, Bading JR, Conti PS. Incidental colonic fluorodeoxyglucose uptake: correlation with colonoscopic and histopathologic findings.Radiology 2002; 224: 783–787.
Atkin WS, Morson BC, Cuzick J. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas.N Engl J Med 1992; 326: 658–662.
Felig DM, Sedarat A, Agress Jr H, Waintraub SE. Colonic adenomas detected by18F-FDG PET.Gastrointestinal Endoscopy 2002; 56: 734.
Yasuda S, Takahashi W, Takagi S, et al. Factors influencing physiological FDG uptake in the intestine.Tokai J Exp Clin Med 1998; 23: 241–244.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Arslan, N., Dehdashti, F. & Siegel, B.A. FDG uptake in colonic villous adenomas. Ann Nucl Med 19, 331–334 (2005). https://doi.org/10.1007/BF02984628
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02984628