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Brown adipose tissue: Evaluation with201Tl and99mTc-sestamibi dual-tracer SPECT

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Abstract

Brown adipose tissue is one kind of adipose tissue and regulates body temperature and balance of energy via non-shivering thermogenesis. The authors present a case that strongly suggested the presence of activated brown adipose tissue in the neck, shoulders and axillary space by increased18F-FDG uptake.99mTc-sestamibi and201Tl dual-tracer SPECT study showed increased 99mTc-sestamibi uptake and non-increased201? uptake in the corresponding18F-FDG uptake sites. Brown adipose tissue has dense mitochondria in the cells, which play an important role in thermogenesis.99mTc-sestamibi uptake and retention depend on the mitochondrial activity but201Tl uptake does not. Therefore, the activity of mitochondria in activated brown adipose tissue may explain the discrepant uptake between99mTc-sestamibi and201Tl.

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Authors and Affiliations

  1. Department of Kanazawa PET Center, Kanazawa Cardiovascular Hospital, Tanakamachi HA-16, Kanazawa, 920-0007, Ishikawa, Japan

    Takahiro Higuchi

  2. Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Japan

    Takahiro Higuchi, Seigo Kinuya, Junichi Taki, Kenichi Nakajima & Norihisa Tonami

  3. Department of Cardiology, Kanazawa Cardiovascular Hospital, Japan

    Masatoshi Ikeda & Masanobu Namura

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  1. Takahiro Higuchi
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  2. Seigo Kinuya
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  3. Junichi Taki
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  4. Kenichi Nakajima
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  5. Masatoshi Ikeda
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  6. Masanobu Namura
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  7. Norihisa Tonami
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Correspondence to Takahiro Higuchi.

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Higuchi, T., Kinuya, S., Taki, J. et al. Brown adipose tissue: Evaluation with201Tl and99mTc-sestamibi dual-tracer SPECT. Ann Nucl Med 18, 547–549 (2004). https://doi.org/10.1007/BF02984575

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  • DOI: https://doi.org/10.1007/BF02984575

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