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Semi-quantitative assessment of oral cavity squamous cell carcinoma using201 TI SPECT for evaluating effectiveness of preoperative radiotherapy

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Abstract

The aim of this study is to reveal the usefulness of semi-quantitative assessment using201 Tl chloride (Tl) single photon emission computed tomography (SPECT) (Tl SPECT) to evaluate the effectiveness of radiotherapy in 15 patients with oral cavity squamous cell carcinma (SCC). Fifteen patients were diagnosed with SCC by biopsy. All 15 patients enrolled in this study were planned to undergo preoperative radiotherapy with or without chemotherapy using carboplatin (CBDCA) and received reduction operation. Tl SPECTs were performed 15 minutes after intravenous administration of 111 MBq201T1 chloride. Regions of Interest (ROI) were set up around tumor (T), and non-lesion (N) at the part of contralateral scalp at the height of the cerebellum. The ratios of mean counts in ROI of the tumor to those in non-lesion were measured as pre- and post-treatment T/N ratios (pre T/N, post T/N). Furthermore, reduction rate (RR) was obtained by calculating [(pre T/N - post T/N)/(pre T/ N)] x 100%. Each parameter (pre T/N, post T/N, and RR) was compared to histopathological grade of surgical specimen based on the Oboshi and Shimosato classification (grade I-IV). RR showed significantly higher values in grade III and IV than in grade I and II (p = 0.0008). In conclusion, semi-quantitative assessment using Tl SPECT, especially calculating RR, is useful to evaluate the effectiveness of preoperative radiotherapy.

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Authors and Affiliations

  1. Oral and Maxillofacial Surgery, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Japan

    Aya Suzuki & Ken Omura

  2. Division of Nuclear Medicine, Chiba Cancer Center, 666-2, Nitona-cho, Chuo-ku, 260-8717, Chiba, Japan

    Aya Suzuki, Takashi Togawa, Junpei Kuyama & Tadaki Nakahara

  3. Division of Surgical Pathology, Chiba Cancer Center, Japan

    Toshinao Takenouchi

  4. Division of Radiation Oncology, Chiba Cancer Center, Japan

    Kazuo Hatano

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  1. Aya Suzuki
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  2. Takashi Togawa
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  3. Junpei Kuyama
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Correspondence to Aya Suzuki.

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Suzuki, A., Togawa, T., Kuyama, J. et al. Semi-quantitative assessment of oral cavity squamous cell carcinoma using201 TI SPECT for evaluating effectiveness of preoperative radiotherapy. Ann Nucl Med 18, 433–441 (2004). https://doi.org/10.1007/BF02984487

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  • DOI: https://doi.org/10.1007/BF02984487

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