Skip to main content
SpringerLink
Log in

The nature of human genetic loads

  • Published:
Journal of Genetics Aims and scope Submit manuscript

Summary

The rare recessive human genes which increase the mortality of inbred human beings may not all be kept in being by mutation. They may include relic genes which were useful in the past but are harmful today. They may also include genes kept in being by greater fitness of the heterozygote at loci where the other homozygote has a lowered fertility rather than a lowered viability.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Arner, G. B. L. (1908).Colombia Univ. studies in history, economics, and public law,31. No. 3, pp. 1–99.

    Google Scholar 

  • Bemiss, S. M. (1858).Trans. Am. Med. Ass.,11, 319–425.

    Google Scholar 

  • Dobzhaksky, Th. (1951).Genetics and the origin of species. Columbia University Press: New York.

    Google Scholar 

  • Haldane, J. B. S. (1937). The effect of variation on fitness.Amer. Nat.,71, 337–349.

    Article  Google Scholar 

  • Haldane, J. B. S. (1954). The measurement of natural selection.Caryologia, Vol. Suppl., 480–487.

  • Kermack, K. A. (1954), A biometrical study ofMicraster coranguinum andM. (Isomicrater) senonensis.Phil. Trans.,B 237, 375–428.

    Google Scholar 

  • Matthew, W. D. (1926). The evolution of the horse: a record and its interpretation.Quart. Rev. Biol.,1, 139.

    Article  Google Scholar 

  • Morton, N. E. Crow, J. F. And Muller, H. J. (1956). An estimate of the mutational damage in man from data on consanguineous marriages.Proc. Nat. Ac. Sci.,42, 855–863.

    Article  CAS  Google Scholar 

  • Neel, J. V. (1963). InGenetic Selection in man (p. 82). Ann Arbor: Univ. Mich.

    Google Scholar 

  • Pearson, K., Lee, A. And Bramley-Moore, L. (1899). Mathematical contributions to the theory of evolution, VI.Phil. Trans. Roy. Soc.,A 192, 257–330.

    Google Scholar 

  • Sutter, J. And Tabah, L. (1952). Effects de la consanguinit’e et de l’endogamic.Population,7, 249–266.

    Google Scholar 

  • Sutter, J. And Tabah, L. (1953), Structure de la mortalit’e dans les familles consanguines.Population,8, 511–526.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Genetics and Biometry Laboratory, Government of Orissa, Bhubaneswar-3, Orissa, India

    J. B. S. Haldane & S. D. Jayakar

Authors
  1. J. B. S. Haldane
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. D. Jayakar
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Haldane, J.B.S., Jayakar, S.D. The nature of human genetic loads. J Genet 59, 53–59 (1965). https://doi.org/10.1007/BF02984144

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02984144

Keywords

Search

Navigation