Conclusions
The foregoing series of experiments, demonstrating the way in which the phenotypedark arises by inheritance, has shown that this type depends upon the presence of at least two genes: (1) the well-known recessive non-agouti, a, in the heterozygous condition; and (2) one or more dominant or semi-dominant modifying factors, U1 [U2…], whose effect is to make non-agouti partially dominant to agouti.
The existence of the modifying factor or factors appears to be evidence in favour of Fisher’s theory of dominance.
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This article is based on a thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy at Brown University in October, 1932. The author wishes to acknowledge his indebtedness to Prof. H. E. Walter under whose direction the work was done.
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Fletcher Barrows, E. Modification of the dominance of agouti to non-agouti in the mouse. Journ. of Genetics 29, 9–15 (1934). https://doi.org/10.1007/BF02981780
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DOI: https://doi.org/10.1007/BF02981780