Summary
This Paper describes the development of theluxate syndrome in mice. The manifold detects of limbs, urogenital system and lumbar vertebrae are traced back to three underlying causes, namely, (i) a craniad shift of the hind-limb girdle, with (ii) imperfect morphogenetic control, or (iii) loss, of the anterior end of the limb field. Craniad shift of the hind-limb region is demonstrable in 101/2-day embryos. The limb defects give rise to defects of the umbilical arteries; these lead to the urogenital defects. A possible unitary hypothesis is discussed, whereby all the effects of theluxate gene could be attributed to a single gene effect, craniacl shift of the hind-limb inductor relative to a supposedly limited region of limb potency.
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An early draft of this paper is referred to as paper III of the series by H. Grüneberg inThe Genetics of the Mouse (second edition, 1952).
I am grateful to Dr H. Grüneberg and to Prof. G. H. Waddington, F.R.S in whose department the work was clone, for stimulating discussions of the problem. The text-figures (except no. 1) were drawn by Mr E. D. Roberts and the photographs taken by Mr D. W. M. Pinkney; Miss C. R. H. Scott and Miss G. I. E. Mavor gave extensive technical assistance; I owe a debt of gratitude to them for their painstaking work.
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Carter, T.C. The genetics of luxate mice. Journ. of Genetics 52, 1–35 (1954). https://doi.org/10.1007/BF02981488
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DOI: https://doi.org/10.1007/BF02981488