Abstract
From the flowers ofChromolaena odorata (Eupatorium odoratum) four flavanones, isosakuranetin (5,7-dihydroxy-4′-methoxyflavanone) (1), persicogenin (5,3′-dihydroxy-7,4′-dimethoxyflavanone) (2), 5,6,7,4′-tetramethoxyflavanone (3) and 4′-hydroxy-5,6,7-trimethoxyflavanone (4), two chalcones, 2′-hydroxy-4,4′,5′,6′-tetramethoxychalcone (5) and 4,2′-dihydroxy-4′, 5′,6′-trimethoxychalcone (6), and two flavones, acacetin (5,7-dihydroxy-4′-methoxyflavone) (7) and luteolin (5,7,3′,4′-tetrahydroxyflavone) (8) were isolated and identified. Compound 1 exhibited moderate antimycobacterial activity againstMycobacterium tuberculosis with the MIC value of 174.8 μM, whereas compounds4,7, and8 exhibited weak activity with the MIC values of 606.0, 704.2 and 699.3 μM respectively. Compound7 showed moderate cytotoxicity against human small cell lung cancer (NCI-H187) cells with the MIC value of 24.6 μM, whereas compound8 exhibited moderate toxicity against NCI-H187 cells and week toxicity against human breast cancer (BC) cells with the MIC values of 19.2 and 38.4 μM respectively.
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Suksamrarn, A., Chotipong, A., Suavansri, T. et al. Antimycobacterial activity and cytotoxicity of flavonoids from the flowers ofChromolaena odorata . Arch Pharm Res 27, 507–511 (2004). https://doi.org/10.1007/BF02980123
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DOI: https://doi.org/10.1007/BF02980123