Abstract
Nine phenolic (1–9) and two furan type (10,11) compounds, were isolated from the methan-olic extract of the tuber ofGastrodia elata Blume (Orchidaceae) in the course of continuing search for platelet anit-aggregating plant components. Compound1 was identified as 4,4′-dihy-droxybenzyl sulfone, a novel compound for the best of our knowledge. Compound10, 5-hydroxymethyl-2-furancarboxaldehyde, was isolated for the first time from this plant. Compound1 (IC50; 83 μM) was about four times more inhibitory to U46619 induced aggregation than ASA (IC50; 340 μM). Compound9, 4,4′-dihydroxy-dibenzylether, (IC50; 5 μM, 3 μM and 33uM, respectively) was 10–80 fold more potent than ASA (IC50; 420 μM, 53 μM and 340 μM respectively) to collagen, epinephrine and U46619 induced aggregation, although it is less active than ASA to AA induced aggregation.
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Pyo, M.K., Jin, J.L., Koo, Y.K. et al. Phenolic and furan type compounds isolated fromGastrodia elata and their anti-platelet effects. Arch Pharm Res 27, 381–385 (2004). https://doi.org/10.1007/BF02980077
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DOI: https://doi.org/10.1007/BF02980077