Abstract
Combinatorial homoserine lactone mixtures and individual products were obtained from the methionine-functionalized resin in solid-phase synthesis. The four-step process consisting of a coupling step of anN-Fmoc-L-methionine, deprotection ofN-Fmoc group,N-coupling with a carboxylic acid, and cleavage reaction through a polymer supported strategy is described. Gas chromatography-mass selective detector (GC-MSD) techniques provide the most powerful methods for identifying both the combinatorial mixtures and individual products.
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Moon, HS. Identification of homoserine lactone derivatives using the methionine functionalized solid phase synthesis by gas chromatography/mass spectrometry. Arch Pharm Res 27, 25–30 (2004). https://doi.org/10.1007/BF02980040
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DOI: https://doi.org/10.1007/BF02980040