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cytotoxic germacranolide sesquiterpene lactones fromCarpesium triste var.manshuricum

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Abstract

Four known germacranolide sesquiterpene lactones, 2α,5-epoxy-5,10-dihydroxy-6α-angeloy-loxy-9β-isobutyloxy-germacran-8α,12-olide (1), 2α,5-epoxy-5,10-dihydroxy-6α, 9β-diangeloy-loxy-germacran-8α,12-olide (2, divaricin B), 2α,5-epoxy-5,10-dihydroxy-6α-angeloyloxy-9β-(2-methylbutyloxy)-germacran-8α,12-olide (3) and 2α,5-epoxy-5,10-dihydroxy-6α-angeloyloxy-9β-(3-methylbutyloxy)-germacran-8α,12-olide (4), were isolated from the chloroform-soluble fraction of the whole plants ofCarpesium triste var.manshuricum. Their chemical structures were determined using spectroscopic methods, including 2D-NMR. All the isolates showed significant cytotoxicities (ED50 value: 4.3–16.8 μM) against five human tumor cell lines; A549, SK-OV-3, SK-MEL-2, XF498 and HCT15.

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Authors and Affiliations

  1. College of Pharmacy, CBITRC, Chungbuk National University, 361-763, Cheongju, Korea

    Mi- Ran Kim, Bang Yeon Hwang, Eun-Sook Jeong, Yong-Moon Lee, Hwan-Soo Yoo, Youn- Bok Chung, Jin Tae Hong & Dong-Cheul Moon

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  1. Mi- Ran Kim
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  2. Bang Yeon Hwang
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  3. Eun-Sook Jeong
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  4. Yong-Moon Lee
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  8. Dong-Cheul Moon
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Correspondence to Dong-Cheul Moon.

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Kim, M.R., Hwang, B.Y., Jeong, ES. et al. cytotoxic germacranolide sesquiterpene lactones fromCarpesium triste var.manshuricum . Arch Pharm Res 30, 556–560 (2007). https://doi.org/10.1007/BF02977648

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  • DOI: https://doi.org/10.1007/BF02977648

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