Abstract
A presenilin 2 mutation is believed to be involved in the development of Alzheimer's disease. In addition, transgenic mice with a presenilin 2 mutation have been reported to have learning and memory impairments. In this study, exposing PC12 cells expressing mutant presenilin 2 to 50 μM Aß25–35, 30 mMl-glutamate and 50 μM H2O2 caused a significant increase in acetylcholine esterase activity. Anin vivo study revealed high levels of this enzyme activity in the mutant presenilin 2 transgenic brains compared with the wild type presenilin 2 transgenic and non-transgenic samples. These results suggest that a mutant presenilin 2-induced neurodegeneration in Alzheimer's disease might be involved in the increase in acetylcholinesterase activity. These findings might help in the development of an appropriate therapeutic intervention targeting mutant presenilin 2-induced Alzheimer's disease.
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Nguyen, H.N., Hwang, D.Y., Kim, Y.K. et al. Mutant presenilin 2 increases acetylcholinesterase activity in neuronal cells. Arch Pharm Res 28, 1073–1078 (2005). https://doi.org/10.1007/BF02977404
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DOI: https://doi.org/10.1007/BF02977404