Abstract
The essential oil fraction ofOstericum koreanum was analyzed by GC-MS. Inhibiting activities of this oil and its main components were tested by the broth dilution assay and disk diffusion test against one antibiotic-susceptible and two resistant strains ofSalmonella enteritidis andS. typhimurium, respectively. The GC-MS analysis revealed thirty-four compounds; the main components were α-pinene (41.12%), ρ-cresol (17.99%) and 4-methylacetophenone (7.90%). The essential oil ofO. koreanum and its main components were significantly effective against the tested antibiotic-susceptible strains as well as against the resistant strains of the twoSalmonella species, with MICs (minimum inhibitory concentrations) ranging from 2 mg/mL to 16 mg/mL. The anti-Salmonella effects of the oils were dose-dependent on Müller-Hinton agar plates in this experiment. Additionally, checkerboard titer test results demonstrated significant combined effects of streptomycin andO. koreanum oil or cresol, one of the main components of this oil, against the two streptomycin resistant strains ofS. typhimurium, with FICIs ranging from 0.12 to 0.37.
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Shin, S. In vitro effects of essential oils fromOstericum koreanum against antibiotic-resistantSalmonella spp.. Arch Pharm Res 28, 765–769 (2005). https://doi.org/10.1007/BF02977340
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DOI: https://doi.org/10.1007/BF02977340