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Antiangiogenic activity ofBupleurum longiradiatum on human umbilical venous endothelial cells

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Abstract

The ethyl acetate fraction ofBupleurum longiradiatum was found to have an inhibitory effect on the tube-like formation of human umbilical venous endothelial (HUVE) cells. The active compounds, isolated from the fraction, were identified as acetylbupleurotoxin (P1) and bupleurotoxin (P2). The compoundsP1 andP2 completely inhibited the tube-like formation of HUVE cells at 30 μg/ml, below the cytotoxic concentration. But, they did not exhibit antitumor activity on BDF1 mice bearing Lewis lung carcinoma cells despite their antiangiogenic activity.

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Authors and Affiliations

  1. College of Pharmacy, Chungnam National University, 305-764, Daejeon, Korea

    Young-Jae You, Im-Seon Lee, Yong Kim, Ki-Hwan Bae & Byung-Zun Ahn

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  1. Young-Jae You
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  2. Im-Seon Lee
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  3. Yong Kim
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  4. Ki-Hwan Bae
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  5. Byung-Zun Ahn
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Correspondence to Byung-Zun Ahn.

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You, YJ., Lee, IS., Kim, Y. et al. Antiangiogenic activity ofBupleurum longiradiatum on human umbilical venous endothelial cells. Arch Pharm Res 25, 640–642 (2002). https://doi.org/10.1007/BF02976936

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  • DOI: https://doi.org/10.1007/BF02976936

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