Abstract
In this study, some aryl (3-methyl-benzofuran-2-yl) ketoximes and their ethers and esters were synthesised. The structure elucidation of the compounds was performed by IR, 1H-NMR, MASS spectroscopy and elemental analyses. Antifungal activities of the compounds were examined and moderate activity was obtained.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Demirayak, §., Uçucu, ü., Benkli, K., Gündoĝdu-Karaburun, N., Karaburun, A.ç., Akar, D., Karabacak, M., and Kiraz, N., Synthesis and antifungal activities of some aryl (benzofuran- 2-yl) ketoximes.Farmaco, 57, 609–612 (2002).
Foye, W. O., Lemke, T. L., and Williams D. A.,Principles of Medicinal Chemistry, 4th ed., Williams and Wilkins, London, pp. 345–387, 499–534, (1995).
Kaneko, S., Uchida, T., Shibuya, S., Honda, T., Kawamoto, I., Harasaki, T., Fukuoka, T., and Konosu, T., Synthesis of sordaricin analogues as potent antifungal agents agains.Candida albicans. Bioorg. Med. Chem. Lett., 12, 803–806 (2002).
Karakurt, A., Dalkara, S., özalp, M., özbey, S., Kendi, E., and Stables, J. P., Synthesis of some 1-(2-naphthyl)-2-(imidazole- 1-yl)ethanone oxime and oxime ether derivatives and their anticonvulsant and antimicrobial activities.Eur. J. Med. Chem., 36, 421–433 (2001).
Massolini, G., Carmellino, M. L., Kitsos, M., and Baruffini, A., Fungicidal activity of new O-derivatives of phenylpyridylke-toximes.Farmaco, 48, 503–514 (1993).
Massolini, G., Carmellino, M. L., and Baruffini, A., Fungicidal activity of O-esters of benzophenone oximes.Farmaco, 49, 747–749 (1994).
Massolini, G., Carmellino, M. L., and Baruffini, A., Fungicidal activity of arylfurylketoximes.Farmaco, 51, 287–292 (1996).
National Committee for Clinical Laboratory Standards. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. Proposed Standard M27–A. Villanova, (1999).
Papadaki-Valiraki, A., Papakonstantinou-Garoufalias, S., Marakos, P., Chytyroglou-Lada, A., Hosoya, M., Balzarini, J., and de Clercq, E., Synthesis, antifungal, antibacterial and antiviral effects of some adamantaneketoxime ethers.Farmaco, 48, 1091–1102 (1993).
Papakonstantinou-Garoufalias, S., Marakos, P., Tsantili-Kakoulidou, A., and Chytyroglou-Ladas, A., Synthesis, lipophilicity and antimicrobial properties of some 0-(5-aryl-1,2,4-triazol-3-yl- ethyl)benzaldoximes and 0-(5-aryl-1,3,4-oxydiazol-2-yl-ethyl) benzaldoximes.Pharmazie, 53, 300–302 (1998).
Pestellini, V., Giolitti, A., Pasqui, F., Abelli, L., Cutrufo, C., De Salvia, G., Evangelista, S., and Meli, A., Synthesis and hypolipidemic activity of new substituted (benzofuran-2-yl)-phenyl-carbinols.Eur. J. Med. Chem., 23, 203–206 (1988).
Raga, M. M., Moreno-Manas, M., Cuberes, M. R., Palacin, C., Castello, J. M., and Ortiz, J. A., Synthesis and antimycotic activity of (benzo[b]thienyl)methyl ethers of 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanol and of (Z)-1-(2,4-dichlorophenyl)- 2-(1H-imidazol-1-yl)ethanone oxime.Arzneimittel-Forschung, 42, 691–694 (1992).
Serrano-Wu, M. H., St. Laurent, D. R., Mazzucco, C. E., Stickle, T. M., Barrett, J. R., Vyas, D. M., and Balasubramanian, B. N., Oxime derivatives of sordaricin as potent antifungal agents.Bioorg. Med. Chem. Lett., 12, 943–946 (2002).
Tungbilek, M., Bozdaĝ, O., Ayhan-Kilcigil, G., Altanlar, N., Buyukbingol, E. and Ertan, R., Synthesis and antimicrobial activity of some new flavonyl oxime ether derivatives.Arzneimittel-Forschung, 49, 853–857 (1999).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Benkli, K., Gündoĝdu-Karaburun, N., Karaburun, A.ç. et al. Synthesis and antifungal activities of some aryl (3-methyl-benzofuran-2-yl) ketoximes. Arch Pharm Res 26, 202–206 (2003). https://doi.org/10.1007/BF02976830
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02976830