Abstract
In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract ofDiospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an IC50 value of 1.85 μg/mL.
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Rho, MC., Chung, M.Y., Song, H.Y. et al. Pheophorbide a-methyl ester, acyl-coa: cholesterol acyltransferase inhibitor fromDiospyros kaki . Arch Pharm Res 26, 716–718 (2003). https://doi.org/10.1007/BF02976679
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DOI: https://doi.org/10.1007/BF02976679