Abstract
Three pseudoguaianolide type sesquiterpenes, bigelovin (1), 2,3-dihydroaromaticin (2), and ergolide (3) were isolated as inhibitory constituents against inducible nitric oxide synthase (iNOS) from the flowers ofInula britannica var. chinensis. Bigelovin (1) exhibited a highly potent inhibitory activity on lipopolysaccharide (LPS)-induced iNOS in murine macrophage RAW 264.7 cells with an IC50 value of 0.46 mM, which is about 8 times more potent than the known selective inhibitor of iNOS, L-N6-(1-iminoethyl)lysine (IC50 3.49 üM). 2,3-Dihydroaroma-ticin (2) and ergolide (3) also exhibited potent inhibitory activities on LPS-induced iNOS with IC50 values of 1.05 and 0.69 üM, respectively.
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Lee, HT., Yang, SW., Kim, K.H. et al. Pseudoguaianolides isolated from inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase. Arch Pharm Res 25, 151–153 (2002). https://doi.org/10.1007/BF02976555
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DOI: https://doi.org/10.1007/BF02976555