Abstract
Geraniol (1), olivetol (2), cannabinoids (3 and4) and 5-fluorouracil (5) were tested for their growth inhibitory effects against human oral epitheloid carcinoma cell lines (KB) and NIH 3T3 fibroblasts using two different 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and sulforhodamine B protein (SRB) assay. Cannabigerol (3) exhibited the highest growth-inhibitory activity against the cancer cell lines.
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Baek, S. H., Yook, C. N., and Han, D. S.: Boron trifluoride etherate on alumina-A modified Lewis acid reagent (V). A convenient single step synthesis of cannabinoids.Bull. Kor. Chem. Soc. 16, 293–296 (1995).
Baek, S. H., Han, D. S., Yook, C. N., Kim, Y. C., and Kwak, J. S.: Synthesis and antitumor activity of cannabigerol.Arch. Pharm. Res. 19, 228–230 (1996).
Baik, K. U., and Ahn, B. Z.: Cytotoxic activities of some geranylated flavones against L 1210 cell.J. Pharm. Soc. Korea 32, 125–128, (1988).
Boersma, H. H., Woerdenbag, H. J., Kampinga, H. H., Konings, A. W. T., Bauer, J. and Scheithauer, W.: Modulation of 5-fluorouracil-induced cytotoxity by quercetin in two human colorectal cancer cell lines.Planta Med. 59, A682 (1993).
Carmichael, J., Degraff, W. G., Gazdar, A. F., Minna, J. D., and Mitchell, J. B.: Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing.Cancer Res. 47, 936–942 (1987).
Dewey, W. L.: Cannabinoid pharmacology.Pharmacol. Rev., 38, 151–178 (1986).
Eisohly, H. N., Turner, C. E., Clark, A. M., and Eisohly, M. A.; Synthesis and antimicrobial activities of certain cannabichromene and cannabigerol related compounds.J. Pharm. Sci. 71, 1319–1323 (1982).
Evans, A. T., Formukong, E. A., and Evans, F. J., Actions of cannabis constituents on enzymes of arachidonate metabolism. Anti-inflammatory potential.Biochem. Pharmacol. 36, 2037–2040 (1987a).
Evans, A. T., Formukong, E. A., and Evans, F. J.; Activation of phospholipase A2 by cannabinoids: lack of correlation with CNS effects.FEB. Lett. 211, 119–122 (1987b).
Formukong, E. A., Evans, A. T., and Evans, F. J.: The inhibitory effects of cannabinoids, The active constituents ofCannabis sativa L. on human and rabbit platelet aggregation.J. Pharm. Pharmacol. 41, 305–309 (1989).
Keepers, Y. P., Pozao, P. E., Peters, G. J., Otte, J. A., Winograd, B., and Pinedo, H. M.: Comparison of the sulforhodamine B protein and tetrazolium (MTT) assys forin vitro chemosensitivity testing.Eur. J. Cancer. 27, 897–900 (1991).
Martin, B.: Cellular effects of cannabinoids.Pharmacol. Rev., 38, 45–74 (1986).
Mechoulam, R.: InCannabinoid as therapeutic agents, Boca Raton, CRC Press Inc., (1986).
Mosmann, T. J.: Rapid colorimetric assays for cellular growth and survival: application to proliferation and cytotoxicity assays.Immunol. Methods. 65, 55–63 (1983).
Plasse, T. F., Gorter, R. W., Krasnow, S. H., Lane, M., Shepard, K. V., and Wadleig H. R. G.: Recent clinical experience with dronabinol.Pharmacol. Biochem. Behav 40, 695–700 (1991).
Skehan, P., Storeng, S., Studiero, D., Monke, A., McMahon, J., Vistica, D., Warren, J. T., Bodesh, H., Kenny, S. and Boyd, M. R.: New colorimetric cytotoxicity assay for anticancer-drug screeningJ. Natl. Cancer Inst, 82, 1107–1112, 1990.
Watson, E. S., Murphy, J. C., and Turner, C. E.: Allergenic properties of naturally occurring cannabinoids.Ibid.. 72, 954–955 (1983).
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Baek, S.H., Kim, Y.O., Kwag, J.S. et al. Boron trifluoride etherate on silica-A modified lewis acid reagent (VII). Antitumor activity of cannabigerol against human oral epitheloid carcinoma cells. Arch. Pharm. Res. 21, 353–356 (1998). https://doi.org/10.1007/BF02975301
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DOI: https://doi.org/10.1007/BF02975301