Abstract
GC-MS analysis on the essential oil (CC-oil) ofCinnamomum cassia stem bark led to the identification of cinnamaldehyde (CNA,1), 2-hydroxycinnamaldehyde (2-CNA), coumarin (2), and cinnamyl acetate. The major volatile flavor in CC-oil was found to be 2-CNA. Coumarin was first isolated from this plant by phytochemical isolation and spectroscopic analysis. CNA and CC-oil showed potent cytotoxicity, which was effectively prevented by N-acetyl-L-cysteine (NAC) treatment. Intraperitoneal administration with CNA considerably decreased malondialdehyde (MDA) formation and glutathione S-transferase activity in rats. These results suggest that CC-oil and CNA can regulate the triggering of hepatic drugmetabolizing enzymes by the formation of a glutathione-conjugate.
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Choi, J., Lee, KT., Ka, H. et al. Constituents of the essential oil of theCinnamomum cassia stem bark and the Biological Properties. Arch Pharm Res 24, 418–423 (2001). https://doi.org/10.1007/BF02975187
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DOI: https://doi.org/10.1007/BF02975187