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Synthesis andIn vitro cytotoxicity of 4-alkyl- or 4-arylaminosub-stituted cyclopenta[c]quinoline derivatives

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  • Medicinal Chemistry & Natural Products
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Abstract

Twelve 4-substituted cyclopenta[c]quinoline derivatives were synthesized and evaluatedin vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, MD-MB-468 and T-47D). The compounds6c and6e bearing p-anisidine and pyrrolidine side chain were more active than the others.

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Authors and Affiliations

  1. College of Pharmacy, Chungbuk National University, 361-763, Cheongju, Korea

    Heesoon Lee & Jeeman Lee

  2. College of Medicine, Kunkuk University, 380-701, Chungju, Korea

    Sung-ll Yang

Authors
  1. Heesoon Lee
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  2. Jeeman Lee
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  3. Sung-ll Yang
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Correspondence to Heesoon Lee.

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Lee, H., Lee, J. & Yang, Sl. Synthesis andIn vitro cytotoxicity of 4-alkyl- or 4-arylaminosub-stituted cyclopenta[c]quinoline derivatives. Arch Pharm Res 24, 385–389 (2001). https://doi.org/10.1007/BF02975180

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  • DOI: https://doi.org/10.1007/BF02975180

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