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Reactions with halogenated compound: Synthesis of several new pyrazolo[3,2-c] triazine and 2-benzenesulfonylglyoxal arylhydrazone derivatives

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Abstract

Diazotized primary artomatic amines4 coupled with the ketosulfones1–3 in ethanol in the presence of sodium acetate at 0°C to afford the corresponding hydrazones5–7. Also diazotized 3-aminopyrazoles14 coupled with1–3 in ethanolic sodium acetate to give the pyrazolotriazines18–20 in good yields. Compounds5–7 and18 can also be obtained from the reaction of hydrazidoyl halides8–10 and21 with sodium benzenesulfinate. The hydrazones11–13 can easy be oxidized to the hydrazones5–7, using hydrogen peroxide in acetic acid.

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Author notes

  1. Abdou O. Abdelhamid

    Present address: Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt

Authors and Affiliations

  1. Department of Science, King Khalid Military Academy, P.O. Box 22140, 11495, Riyadh, Saudi Arabia

    Abdou O. Abdelhamid

  2. Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt

    Fawzy A. Attaby & Fathy A. Khalifa

  3. National Organization for Drug Control and Research, P.O. Box 29, Cairo, A.R. Egypt

    Sami S. Ghabrial

Authors
  1. Abdou O. Abdelhamid
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  2. Fawzy A. Attaby
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  3. Fathy A. Khalifa
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  4. Sami S. Ghabrial
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Abdelhamid, A.O., Attaby, F.A., Khalifa, F.A. et al. Reactions with halogenated compound: Synthesis of several new pyrazolo[3,2-c] triazine and 2-benzenesulfonylglyoxal arylhydrazone derivatives. Arch. Pharm. Res. 15, 14–19 (1992). https://doi.org/10.1007/BF02973978

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  • DOI: https://doi.org/10.1007/BF02973978

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