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Cytotoxic sesquiterpene lactones fromSaussurea calcicola

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Abstract

Seven sesquiterpene lactones were isolated by the chromatographic separation of the MeOH extract of the aerial parts ofSaussurea calcicola (Compositae). Their structures were determined spectroscopically to be cynaropicrin (1), arguerin B (2), cebellin F (3), 8α-hydroxy-11α, 13-dihydrozaluzanin C (4), desacylcynaropicrin (5), 3β-hydroxy-8α-epoxymethylacriloiloxy-4(15), 10(14), 11(13)-trien-guaian-6, 12-olide (6), and kandavanolide (7). Compounds1 and2 showed significant cytotoxicity against five cultured human tumor cell lines with ED50 values ranging from 0.23≈1.72 μg/mL.

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Authors and Affiliations

  1. Natural Products laboratory, College of Pharmacy, Sungkyunkwan University, 440-746, Suwon, Korea

    Sang Zin Choi & Kang Ro Lee

  2. Korea Research Institute of Chemical Technology, 305-600, Taejeon, Korea

    Sang Un Choi

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  1. Sang Zin Choi
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  2. Sang Un Choi
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Correspondence to Kang Ro Lee.

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Choi, S.Z., Choi, S.U. & Lee, K.R. Cytotoxic sesquiterpene lactones fromSaussurea calcicola . Arch Pharm Res 28, 1142–1146 (2005). https://doi.org/10.1007/BF02972976

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  • DOI: https://doi.org/10.1007/BF02972976

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