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Integrated cardiac PET-CT for the diagnosis and management of CAD

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Journal of Nuclear Cardiology Aims and scope

Conclusions

The clinical evidence discussed previously suggests that integrated PET-CT is a powerful noninvasive modality for diagnosing and managing CAD. The need for gated scans, the use of nephrotoxic contrast, and the potential limitations imposed by the presence of calcium bring into question the generalizability of CT alone to all patients with known or suspected CAD. Beyond diagnosis of CAD, CT coronary angiography may find its most important challenge in guiding management after the diagnosis of CAD is established. Thus the greatest strength of integrated PET-CT imaging is its ability to establish the diagnosis, define risk, and guide management with a single study.

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References

  1. Weiner DA, Ryan TJ, McCabe CH, Chaitman BR, Sheffield LT, Fisher LD, et al. The role of exercise testing in identifying patients with improved survival after coronary artery bypass surgery. J Am Coll Cardiol 1986;8:741–8.

    Article  PubMed  CAS  Google Scholar 

  2. Hachamovitch R, Hayes SW, Friedman JD, Cohen I, Berman DS. Identification of a threshold of inducible ischemia associated with a short-term survival benefit with revascularization compared to medical therapy in patients with no prior cad undergoing stress myocardial perfusion SPECT. Circulation 2003;107:2899–906.

    Article  Google Scholar 

  3. Yusuf S, Zucker D, Peduzzi P, Fisher LD, Takaro T, Kennedy JW, et al. Effect of coronary artery bypass graft surgery on survival: overview of 10-year results from randomised trials by the Coronary Artery Bypass Graft Surgery Trialists Collaboration. Lancet 1994;344:563–70.

    Article  PubMed  CAS  Google Scholar 

  4. Di Carli M, Czernin J, Hoh CK, Gerbaudo VH, Brunken RC, Huang SC, et al. Relation among stenosis severity, myocardial blood flow, and flow reserve in patients with coronary artery disease. Circulation 1995;91:1944–51.

    Google Scholar 

  5. Uren NG, Melin JA, De Bruyne B, Wijns W, Baudhuin T, Camici PG. Relation between myocardial blood flow and the severity of coronary-artery stenosis. N Engl J Med 1994;330:1782–8.

    Article  PubMed  CAS  Google Scholar 

  6. Hoff JA, Chomka EV, Krainik AJ, Daviglus M, Rich S, Kondos GT. Age and gender distributions of coronary artery calcium detected by electron beam tomography in 35,246 adults. Am J Cardiol 2001;87:1335–9.

    Article  PubMed  CAS  Google Scholar 

  7. Hoff JA, Quinn L, Sevrukov A, Lipton RB, Daviglus M, Garside DB, et al. The prevalence of coronary artery calcium among diabetic individuals without known coronary artery disease. J Am Coll Cardiol 2003;41:1008–12.

    Article  PubMed  CAS  Google Scholar 

  8. Nieman K, Rensing BJ, van Geuns RJ, Vos J, Pattynama PM, Krestin GP, et al. Non-invasive coronary angiography with multislice spiral computed tomography: impact of heart rate. Heart 2002;88:470–4.

    Article  PubMed  CAS  Google Scholar 

  9. American Heart Association. Heart disease and stroke statistics— 2005 update. Available from: URL: http://www.americanheart.org/ downloadable/heart/1105390918119HDSStats2005Update.pdf. Accessed March 1, 2005.

  10. Hachamovitch R, Hayes SW, Friedman JD, Cohen I, Berman DS. Comparison of the short-term survival benefit associated with revascularization compared with medical therapy in patients with no prior coronary artery disease undergoing stress myocardial perfusion single photon emission computed tomography. Circulation 2003;107:2900–7.

    Article  PubMed  Google Scholar 

  11. Uren NG, Crake T, Lefroy DC, de Silva R, Davies GJ, Maseri A. Reduced coronary vasodilator function in infarcted and normal myocardium after myocardial infarction. N Engl J Med 1994;331:222–7.

    Article  PubMed  CAS  Google Scholar 

  12. Yoshinaga K, Katoh C, Noriyasu K, Iwado Y, Furuyama H, Ito Y, et al. Reduction of coronary flow reserve in areas with and without ischemia on stress perfusion imaging in patients with coronary artery disease: a study using oxygen 15-labeled water PET. J Nucl Cardiol 2003;10:275–83.

    Article  PubMed  Google Scholar 

  13. Di Carli MF, Dorbala S, Limaye A, et al. Clinical value of hybrid PET/CT cardiac imaging: complementary roles of multi-detector CT coronary angiography and stress PET perfusion imaging [abstract]. J Am Coll Cardiol 2006;47:115A.

    Google Scholar 

  14. Leber AW, Knez A, von Ziegler F, Becker A, Nikolaou K, Paul S, et al. Quantification of obstructive and nonobstructive coronary lesions by 64-slice computed tomography: a comparative study with quantitative coronary angiography and intravascular ultrasound. J Am Coll Cardiol 2005;46:147–54.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Divisions of Nuclear Medicine/PET, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St, 02115, Boston, Mass

    Marcelo F. Di Carli, Sharmila Dorbala & Rory Hachamovitch

  2. Cardiovascular Imaging, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, 02115, Boston, Mass

    Marcelo F. Di Carli

  3. Cardiovascular Medicine Division, Department of Medicine, University of Southern California, Los Angeles, Calif.

    Sharmila Dorbala

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  1. Marcelo F. Di Carli
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  2. Sharmila Dorbala
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  3. Rory Hachamovitch
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Correspondence to Marcelo F. Di Carli.

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Carli, M.F.D., Dorbala, S. & Hachamovitch, R. Integrated cardiac PET-CT for the diagnosis and management of CAD. J Nucl Cardiol 13, 139–144 (2006). https://doi.org/10.1007/BF02971234

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  • DOI: https://doi.org/10.1007/BF02971234

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