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Glucose biosensor enhanced by nanoparticles

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Abstract

Glucose biosensors have been formed with glucose oxidase (GOD) immobilized in composite immobilization membrane matrix, which is composed of hydrophobic gold, or hydrophilic gold, or hydrophobic silica nanoparticles, or the combination of gold and silica nanoparticles, and polyvinyl butyral (PVB) by a sol-gel method. The experiments show that nanoparticles can significantly enhance the catalytic activity of the immobilization enzyme. The current response can be increased from tens of nanoamperometer (nA) to thousands of nanoamperometer to the same glucose concentration, and the electrodes respond very quickly, to about 1 min. The function of nanoparticles effect on immobilization enzyme has been discussed.

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Authors and Affiliations

  1. Institute of Photographic Chemistry, Chinese Academy of Sciences, 100101, Beijing, China

    Fangqiong Tang & Dong Chen

  2. Inorganic Materials Department, Sichuan University, 610065, Chengdu, Chin

    Xianwei Meng, Junguo Ran & Changqiong Zheng

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  1. Fangqiong Tang
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  2. Xianwei Meng
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  3. Dong Chen
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  4. Junguo Ran
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  5. Changqiong Zheng
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Correspondence to Fangqiong Tang.

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Tang, F., Meng, X., Chen, D. et al. Glucose biosensor enhanced by nanoparticles. Sc. China Ser. B-Chem. 43, 268–274 (2000). https://doi.org/10.1007/BF02969521

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  • DOI: https://doi.org/10.1007/BF02969521

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