Abstract
From the leaves ofGoniothalamus tenuifolius, a new natural product namely 3′-hydroxy-3,5,7,4′-tetramethoxyflavone (1) was isolated, along with seven other known compounds (2–8). Each of these isolates was evaluated for free radical scavenging activity on the DPPH decoloration test. The data obtained in this study suggested that theortho 3′,4′-diphenolic structure was essential for the activity of these flavonol derivatives.
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Beutler, J. A., Hamel, E., Vlietinch, A. J., Haemers, A., Rajan, P., Roitman, J. N., Cardellina II, J. H., and Boyd, M. R., Structure-activity requirements for flavone cytotoxicity and binding to tubulin.J. Med. Chem., 41, 2333–2338 (1998).
Bouktaib, M., Lebrun, S., Atmani, A., and Rolando, C., Hemisynthesis of all theO-monomethylated analogues of quercetin including the major metabolites, through selective protection of phenolic functions.Tetrahedron, 58, 10001–10009 (2002).
Braca, A., Sortino, C., Politi, M., Norelli, I., and Mendez, J., Antioxidant activity of flavonoids fromLicania licaniaeflora.J. Ethnopharmacology, 79, 379–381 (2002).
Dong, H., Gou, Y-L., Cao, S-G., Chen, S-X., Chen, K-Y., Goh, S-H., and Kini, R. M., Eicosenones and methylated flavonols fromAmomum koenigii.Phytochemistry, 50, 899–902 (1999).
Hanai, K., Kuwae, A., Takai, T., Senca, H., and Kunimoto, K-K., A comparative vibrational and NMR study ofcis-cinnamic acid polymorphs andtrans-cinnamic acid.Spectrochim. Acta Part A, 57, 513–519 (2001).
Higa, M., Miyagi, Y., Togi, S., and Hokama, K., Flavonoid constituents ofMelicope triphylla Merr.Yakugaku Zasshi, 107, 954–958 (1987).
Itokawa, H., Suto, K., and Takeya, K., Studies on a novelp-coumaroyl glucoside of apigenin and on other flavonoids isolated from Patchouli (Labiatae).Chem. Pharm. Bull., 29, 254–256 (1981).
Likhitwitayawuid, K., Wirasathien, L., Jongboonprasert, V., Aimi, N., Takayama, H., and Kitajima, M., Antimalarial alkaloids fromGoniothalamus tenuifolius.Pharm. Pharmacol. Lett., 7, 99–102 (1997).
Markham, K. R., Techniques of flavonoids identification. London: Academic Press, pp. 38–39 (1982).
Ohashi, H., Kyogaku, T., Isikawa, T., Kawase, S-I., and Kawai, S., Antioxidative activity of tree phenolic constituents I: Radical-capturing reaction of flavon-3-ols with radical initiator.J. Wood. Sci., 45, 53–63 (1999).
Parmar, V. S., Bisht, K. S., Jain, R., Singh, S., Sharma, S. K., Gupta, S., Synthesis, antimicrobial and antiviral activities of novel polyphenolic compounds.Indian J. Chem., 35B, 220–232 (1996).
Parmar, V. S., Jain, R., Sharma, S. K. Vardhan, A., Jha, A., Taneja, P., Singh, S., Vyncke, B. M., Bracke, M. E., and Mareel, M. M., Anti-invasive activity of 3,7-dimethoxyflavonein vitro.J. Pharm. Sci., 83, 1217–1221 (1994).
Takao, T., Kitatani, F., Watanabe, N., Yaki, A., and Sakata, K., A simple screening method for antioxidants and isolation of several antioxidants produced by marine bacteria from fish and shellfish.Biosci. Biotech. Biochem., 58, 1780–1783 (1994).
Urbatsch, L. E., Bacon, J. D., and Mabry, T. J., Flavonols methyl ethers fromChrysothamnus viscidilorus.Phytochemistry, 14, 2279–2282 (1975).
Urbatsch, L. E., Mabry, T. J., Miyakado, M., Ohno, N., and Yoshioka, H., Flavonol methyl ethers fromEricameria diffusa.Phytochemistry, 15, 440–441 (1976).
Wang, Y., Hamburger, M., Gueho, J., and Hostettmann, K., Antimicrobial flavonoids fromPsiadia trinervia and their methylated and acetylated derivatives.Phytochemistry, 28, 2323–2327 (1989).
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Likhitwitayawuid, K., Klongsiriwet, C., Jongbunprasert, V. et al. Flavones with free radical scavenging activity fromGoniothalamus tenuifolius . Arch Pharm Res 29, 199–202 (2006). https://doi.org/10.1007/BF02969393
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DOI: https://doi.org/10.1007/BF02969393