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Problèmes de carcinogénèse sur le bas œsophage

Adenocarcinogenesis on the lower esophagus

  • Published:
Acta Endoscopica

Résumé

Si l'association alcoolisme-tabagisme constitue un facteur déterminant dans la carcinogenèse malpighienne de la voie digestive proximale (bouche, pharynx, margelle laryngée, œsophage), le reflux gastro-œsophagien chronique pourrait jouer un rôle analogue dans la genèse de l'adéno-carcinome de l'œsophage terminal et du cardia. A partir de la forme chronique de l'œsophagite par reflux, le processus carcinogénique paraît être lié ici au phénomène intermédiaire de l'épithélisation métaplasique cylindrique des ulcérations peptiques du bas-œsophage. L'analyse de 1032 cas d'œsophagite peptique érosive a permis quelques considérations concernant cette double étape dans l'adéno-carcinogenèse de la jonction œso-gastrique.

Summary

If the association between alcohol and smoking is considered as a chief factor in the squamous carcinogenesis of the proximal digestive tract (mouth, pharynx, laryngeal edge, esophagus), the chronic gastro-esophageal reflux might have a similar role to play in the origin of the adeno-carcinoma of the lower esophagus and the cardia.

Arising in a chronic peptic esophageal condition, the adeno-carcinogenetic process seems to be bound with the intermediate phenomenon of the metaplastic columnar cicatrisation of the peptic ulcerations of the lower esophagus.

The analysis of 1032 cases of erosive peptic esophagitis has allowed some considerations about these two steps in the adeno-carcinogenesis of the esogastric junction.

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  1. Clinique universitaire O.R.L., C.H.U.V., 1011, Lausanne, Suisse

    M. Savary & G. Guignard

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  1. M. Savary
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  2. G. Guignard
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Savary, M., Guignard, G. Problèmes de carcinogénèse sur le bas œsophage. Acta Endosc 7, 217–230 (1977). https://doi.org/10.1007/BF02968431

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  • DOI: https://doi.org/10.1007/BF02968431

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