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Parathyroid hormone-related protein in breast cancer tissues: Relationship between primary and metastatic sites

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Abstract

The expression of parathyroid hormone-related protein (PTHrP) at primary and metastatic sites was studied retrospectively in specimens obtained at operation and autopsy from 11 patients. The anti-human PTHrP monoclonal antibody, 4B3, was used in the immunohistochemical studies. The 11 cases showed metastases to the liver and the lung, and 9 showed bone metastases at autopsy. At primary sites, PTHrP was positive in the 9 cases with bone metastases, while the other 2 cases were negative for PTHrP. Regardless of the intensities of immunohistochemical staining of PTHrP at primary sites, cancer cells at metastatic sites in the liver and the lung were almost all negative for PTHrP. On the other hand, all PTHrP-positive cases at primary sites at operation showed skeletal metastases at autopsy, and the intensity of the immunohistochemical staining of PTHrP was strongly positive at all the sites of skeletal metastasis. These results suggest that while PTHrP is an important factor that causes cancer cells to erode and grow in skeletal bone, the expression of PTHrP is, concurrently, affected by an osseous microenvironment.

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Abbreviations

HHM:

Humoral hypercalcemia of malignancy

MoAb:

Monoclonal antibody

PTH:

Parathyroid hormone

PTHrP:

Parathyroid hormone-related protein

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Authors and Affiliations

  1. Department of Surgery, Hyogo Medical Center for Adults, 1-7 Kitaoji-cho, 651, Akashi, Japan

    Norio Kohno, Youko Sakoda, Yoshihiro Kanbara, Yoshihiko Furuya & Osamu Ohashi

  2. Second Department of Pathology, Kobe University School of Medicine, Japan

    Sohei Kitazawa

  3. Third Division, Department of Medicine, Kobe University School of Medicine, Japan

    Riko Kitazawa

Authors
  1. Norio Kohno
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  2. Sohei Kitazawa
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  3. Youko Sakoda
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  4. Yoshihiro Kanbara
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  5. Yoshihiko Furuya
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  6. Osamu Ohashi
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  7. Riko Kitazawa
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Supported in part by Grant-in-Aid from Ministry of Education of Japan.

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Kohno, N., Kitazawa, S., Sakoda, Y. et al. Parathyroid hormone-related protein in breast cancer tissues: Relationship between primary and metastatic sites. Breast Cancer 1, 43–49 (1994). https://doi.org/10.1007/BF02967374

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  • DOI: https://doi.org/10.1007/BF02967374

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