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MDM2 in breast cancer

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Abstract

TheMDM2 protein, an oncogene product, is known to act by suppressing p53 function. Although gene amplification ofMDM2 was frequently detected in human sarcomas, it was uncommon in the majority of epithelial tumors including breast cancer. However, recent reports have demonstrated that its translational activity is enhanced in a variety of carcinomas. In this report, we summarized the implications ofMDM2 overexpression in human breast cancer from the literature as well as our preliminary results.

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Abbreviations

ER:

Estrogen receptor

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Authors and Affiliations

  1. Department of Surgery, Tokyo Metropolitan Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, 113, Tokyo, Japan

    Masakazu Toi, Shigehira Saji, Akio Suzuki, Yutaka Yamamoto & Takeshi Tominaga

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  1. Masakazu Toi
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  2. Shigehira Saji
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  3. Akio Suzuki
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  4. Yutaka Yamamoto
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  5. Takeshi Tominaga
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Toi, M., Saji, S., Suzuki, A. et al. MDM2 in breast cancer. Breast Cancer 4, 264–268 (1997). https://doi.org/10.1007/BF02966519

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