Skip to main content
SpringerLink
Log in

The role of azithromycin in the treatment ofHelicobacter pylori infection—A retrospective report

  • Addendum
  • Published:
Infection Aims and scope Submit manuscript

Summary

The aim of this study is to present an overview of azithromycin (AZI)-basedHelicobacter pylori eradication therapies which have been used to date. AllH. pylori therapy studies involving AZI published between January 1990 and July 1997 were analyzed. Mono- and quadruple therapies were rare and not important. Dual therapies of 14 separate treatment arms with 323 patients yieldedH. pylori erdication rates of 15 to 90% ITT (per intention to treat). In 19 triple therapies with 724 patients, AZI was combined with either a proton pump inhibitor or bismuth, and amoxicillin, metronidazole, or tinidazole. HigherH. pylori eradication rates were attained in these arms, ranging from 39 to 92% ITT and from 47 to 94% pp (per protocol), compared to the dual therapies. The most successful combination therapy (H. pylori eradication rates =95% pp and 92% ITT) found in this analysis consisted of pantoprazole (2×40 mg daily) in combination with AZI (1×50 mg daily) and tinidazole (1×2,000 mg daily), given as a single dose 2 h after breakfast for 6 days. This study shows that of the AZI therapies used so far, combinations of AZI and tinidazole are the most successful at eradicatingH. pylori.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Marschall, B. J., Warren, J. R.: Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet i (1984) 1311–1314.

    Article  Google Scholar 

  2. Warren, J. R., Marschall, B. J.: Unidentified curved bacilli on gastric epithelium in chronic gastritis. Lancet i (1983) 1273–1275.

    Google Scholar 

  3. Hulst van der René, W. M., Keller, J. J., Rauws, A. J., Tytgat, G. N. J.: Treatment ofHelicobacter pylori infection: a review of the world literature. Helicobacter 1 (1996) 6–19.

    Article  Google Scholar 

  4. Laurent, K.: Efficacy, safety, and tolerability of azithromycin versus roxithromycin in the treatment of acute lower respiratory tract infections. J. Antimicrob. Chemother. 37 (Suppl. C) (1996) 115–124.

    PubMed  CAS  Google Scholar 

  5. Müller, O.: Comparison of azithromycin versus clarithromycin in the treatment of patients with upper respiratory tract infections. J. Antimicrob. Chemother. 31 (Suppl E) (1993) 137–146.

    PubMed  Google Scholar 

  6. Müller, O.: An open comparative study of azithromycin and roxithromycin in the treatment of acute lower respiratory tract infections. J. Antimicrob. Chemother. 37 (Suppl C) (1996) 83–92.

    PubMed  Google Scholar 

  7. Pozzi, E., Grossi, E., Pecori, A. and the Azithromycin Research Group: Azithromycin versus clarithromycin in the treatment of acute exacerbation of chronic bronchitis. Curr. Ther. Res. 55 (1994) 759–764.

    Article  Google Scholar 

  8. Principi, N.: Multicentre comparative study of the efficacy and safety of azithromycin compared with amoxicillin clavulanic acid in the treatment of paediatric patients with otitis media. Eur. J. Clin. Microbiol. Infect. Dis. 14 (1995) 669–676.

    Article  PubMed  CAS  Google Scholar 

  9. Harrison, J. D., Jones, J. A., Morris, D. L.: Azithromycin levels in plasma and gastric tissue, juice, and mucus. Eur. J. Clin. Microbiol. Infect. Dis. 10 (1991) 862–864.

    Article  PubMed  CAS  Google Scholar 

  10. Glupczynski, Y., Burette, A.: Failure of azithromycin to eradicateCampylobacter pylori from the stomach because of acquired resistance during treatment (letter). Am. J. Gastroenterol. 85 (1990) 98.

    PubMed  CAS  Google Scholar 

  11. Marchi, M., Vacondio, R., Bagnulo, A. Mengoli, M.: Azithromycin-omeprazole treatment for eradication ofHelicobacter pylori. Azitromicins-omeprazolo. Trattamento per eradicazione diHelicobacter pylori. Minerva Gastroenterol. Dietol. (1994) 47–49.

  12. Bronisch, H.-J.: Heilung derHelicobacter pylori-Infektion. Der Allgemeinarzt 1 (1996) 110–112.

    Google Scholar 

  13. Di Mario, F., Dal Bo, N., Ferrana, M., Salandin, S., Dotto, P., Del Bianco, T., Vianello, F., Vigneri, S., Rugge, M., Grassi, S. A., Battaglia, G.: Azithromycin in a triple therapy for eradication ofHelicobacter pylori. Gut 35 (Suppl. 2) (1994) F249.

    Google Scholar 

  14. Di Mario, F., Dal Bo, N., Grassi, S. A., Rugge, M., Cassaro, M., Donisi, P. M., Vianello, F., Kusstatscher, S., Salandin, S., Grasso, G. A., Ferrana, M., Battaglia, G.: Azithromycin for the cure ofHelicobacter pylori infection. Am. J. Gastroenterol. 1 (1996) 264–267.

    Google Scholar 

  15. Bertoni, G., Sassatelli, R., Nigrisoli, E., Tansini, P., Bianchi, G., Della Casa, G., Bagni, A., Bedogni, G.: Triple therapy with azithromycin, omeprazole, and amoxicillin is highly effective in the eradication ofHelicobacter pylori. a controlled trial versus omeprazole plus amoxicillin. Am. J. Gastroenterol. 91 (1996) 258–263.

    PubMed  CAS  Google Scholar 

  16. Caselli, M., Trevisani, L., Tursi, A., Sartori, S., Ruina, M., Luzzi, M., Gaudenzi, P., Alvisi, V., Gasbarrini, G.: Short-term low-dose triple therapy with azithromycin, metronidazole and lansoprazole appears highly effective for the eradication ofHelicobacter pylori. Eur. J. Gastroenterol. Hepatol. 9 (1997) 45–48.

    PubMed  CAS  Google Scholar 

  17. Dohmen, W., Seelis, R.: Ulcusheilung trotz Rauchen. Abheilung von zwei großenH. pylori-infizierten Ulzera duodeni mit einer neuen 6-Tages-Eradikationstherapie. Praxismagazin Med. 7 (1996) 42–43.

    Google Scholar 

  18. Dohmen, W., Seelis, R.: Helicobacter-Therapie in der Praxis. Z. Allg. Med. 72 (1996), 1431–1433.

    Google Scholar 

  19. Dohmen, W., Seelis, R.: Open questions ofH. pylori eradication therapy in the treatment of primary-care patients from less developed countries. Gut 39 (Suppl. 2) (1996) A21.

    Google Scholar 

  20. Seelis, R., Dohmen, W.: 6-dayH. pylori eradication therapy in primary care medicine using azithromycin, tinidazole, pantoprazole. Gastroenterology 112 (Suppl. 4) (1997) A284.

    Google Scholar 

  21. Seelis, R., Dohmen, W.: The synergistic effect of azithromycin and tinidazole in eradicatingHelicobacter pylori. Gut 41 (Suppl. 1) (1997) A102.

    Google Scholar 

  22. Seelis, R., Dohmen, W.: Eradication ofHelicobacter pylori (Hp): synergistic effect of azithromycin and tinidazole but not amoxicillin. Gut 41 (Suppl. 3) (1997) A208.

    Google Scholar 

  23. Al-Assi, M. T., Genta, R. M., Karttunen, T. J., Cote, R. A., Graham, D. Y.: Azithromycin triple therapy forHelicobacter pylori infection: azithromycin, tetracycline, and bismuth. Am. J. Gastroenterol. 90 (1995) 403–405.

    PubMed  CAS  Google Scholar 

  24. Caselli, M., Ruina, M., Gallerani, L., Fabbri, P., Gaudenzi, P., Alvisi, V.: Azithromycin and increasing doses of omeprazole for the eradication ofHelicobacter pylori. Gut 39 (Suppl. 2) (1996) A31.

    Google Scholar 

  25. Peters, K. U.: Review article: omeprazole and the cytochrome P450 system. Aliment. Pharmacol. Ther. 9 (1995) 1–9.

    Article  Google Scholar 

  26. Garatti, G., Squillaci, S., Pecunia, C., Deantoni, A.: Eradicating therapy ofHelicobacter pylori. in the duodenal ulcer. Minerva Gastroenterol. Dietol. 43 (1997) 7–18.

    PubMed  CAS  Google Scholar 

  27. Deltenre, M., Jonas, C., Otero, J., Lozzoli, A., Denis, P., Burette, A., De Koster, E.: Strategies forHelicobacter pylori eradication in 1995: a review of international and Belgian experience. J. Physiol. Pharmacol. 47 (1996) 59–69.

    PubMed  CAS  Google Scholar 

  28. Rossario, M., Omar, R., Santos, J. A., Alves, I., Sales-Luis, A.: Efficacy of an anti-Helicobacter pylori triple therapy regimen in a routine clinical practice setting.Helicobacter pylori: Basis mechanisms to clinical cure conference. Ottawa 1996, pp. 10–12, poster abstr. 65.

  29. Labenz, J., Tillenburg, B., Peitz, U., Köhl, H., Becher, T., Stolte, M., Börsch, G.: Ulcusheilung durchHelicobacter pylori-Eradikation: genügt eine Woche Therapie? Dtsch. Med. Wochenschr. 121 (1996) 3–8.

    Article  PubMed  CAS  Google Scholar 

  30. Dohmen, W., Seelis, R.: Complete ulcer healing following 6-dayH. pylori eradication without maintenance acid suppression. Gastroenterology 112 (1997) A104.

    Google Scholar 

  31. Bago, J., Kucisec, N., Bilic, A. Bakula, V., Jurcic, D.: Efficiency of omeprazole, combination of omeprazole and azithromycin, and combination of omeprazole and amoxicillin in eradication ofHelicobacter pylori: a prospective randomised study. Croat. Gastroenterol. Hepatol. 4 (1995) 43–47.

    Google Scholar 

  32. Bokemeyer, B.: Kombinierte Therapie mit Azithromycin und Omeprazol zur Eradikation vonHelicobacter pylori. Dtsch. Med. Wochenschr. 120 (1995) 1339.

    PubMed  CAS  Google Scholar 

  33. Cammarota, G., Tursi, A., Papa, A., Montalto, M., Veneto, G., Cuoco, L., Fedeli, G., Gasbarrini, G.: Azithromycin/omeprazole vs. omeprazole/amoxicillin/tinidazole vs omeprazole/amoxicillin for the treatment ofH. pylori infection. Ital. J. Gastroenterol. 26 (Suppl. 2) (1994) 35–36.

    Google Scholar 

  34. Cammarota, G., Tursi, A., Papa, A., Montalo, M., Veneto, G., Cuoco, L., Fedeli, G., Gasbarrini, G.:Helicobacter pylori eradication using one-week low-dose lansoprazole plus amoxicillin and either clarithromycin or azithromycin. Aliment. Pharmacol. Ther. 10 (1996) 997–1000.

    Article  PubMed  CAS  Google Scholar 

  35. Marchegiani, A., Di Capua, F.: Combined omeprazole/azithromycin therapy regimen for eradication ofHelicobacter pylori. Acta Gastroenterol. Belg. (Suppl. 56) (1993) 141.

    Google Scholar 

  36. Patiti, M.: A new therapeutic strategy for the eradication ofHelicobacter pylori infection. Minerva Gastroenterol. Dietol. 42 (1996) 237–238.

    PubMed  CAS  Google Scholar 

  37. Pilotto, A., Franceschi, M., Bozzola, L., Battaglia, G., Scagnelli, M., Fabrello, R., Dal Bo, N., Vianello, F., Ferrarese, S., Di Mario, F.: Double therapy (omeprazole plus azithromycin or clarithromycin) for eradication ofHelicobacter pylori in the elderly. Am. J. Gastroenterol. 89 (1994) 1385.

    Google Scholar 

  38. Pilotto, A., Franceschi, M., Battaglia, G., Grassi, S. A., Bozzola, L., Dal Bo, N., Ferrana, M., Scagnelli, M., Salandi, S., Di Mario, F.: Eradication ofHelicobacter pylori in the elderly: triple versus double therapy. Am J. Gastroenterol. 89 (1994) 1386.

    Google Scholar 

  39. Pilotto, A., Franceschi, M., Bozzola, L., Fortunato, A., Dal Bo, N., Scagnelli, M., Fabrello, R., Soffiati, G., Meli, V., Oliani, G., Di Mario, F.: The cure forHelicobacter pylori (HP) infection with double or triple omeprazole-based therapies in the elderly: effects on eradication rate, chronic gastritis, and serum anti-Hp antibodies and pepsinogenes. Digestive Disease Week. 14–17 May, 1995, San Diego. California, USA. abstr. 3643.

  40. Shonová, O., Petr. P., Hausnev, O.: Azithromycin as a promising part of helicocidal regimens ICMAS III, 24–27, January 1996. Lisbon, Portugal, poster.

  41. Spadaccini, A., Sciampa, G., De Fanis, C., Pizzicanella, G., Pantaleone, U., Magnarini, C., Trubiani, O.: Colloidal bismuth subcitrate (CBS) in combination with azithromycin (AZ) for the eradication ofHelicobacter pylori (HP) associated gastritis. 10th World Congress of Gastroenterology, 2–4 October 1994. Los Angeles. California, USA, abstr. II, 778.

  42. Tursi, A., Cammarota, G., Montalto, M., Papa, A., Cuoco, L., Veneto, G. M., Cannizzaro, O., Fedeli, G., Gasbarrini, G.: Evaluation of the efficacy and tolerability of four different therapeutic regimes forHelicobacter pylori eradication. Panminerva Medica 38 (1996) 145–149.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lehrpraxis für Allgemeinmedizin, Thomashofstr. 3, D-57070, Aachen, Germany

    W. Dohmen

  2. Gastroenterologische Facharztpraxis, Theaterpl. 9–11, D-52062, Aachen, Germany

    R. E. A. Seelis

Authors
  1. W. Dohmen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. E. A. Seelis
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dohmen, W., Seelis, R.E.A. The role of azithromycin in the treatment ofHelicobacter pylori infection—A retrospective report. Infection 26, 256–262 (1998). https://doi.org/10.1007/BF02962382

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02962382

Keywords

Search

Navigation