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The coagulative factors of normal human and human cancer tissue

  • Published:
Irish Journal of Medical Science (1926-1967)

Summary

  1. 1.

    Human cancer tissues are characterised by deposition of fibrin.

  2. 2.

    Aqueous extracts of cancer tissue contain labile factors which cause coagulation in buffered diluted human plasma.

  3. 3.

    The coagulative factors of cancer tissue have been fractionated by chromatography on DEAE cellulose into four main groups, A, B, C and D.

  4. 4.

    Comparable extracts of normal human tissues show either negligible coagulative activity or a small amount of activity corresponding roughly to group B.

  5. 5.

    Starch block electrophoresis of cancer tissue extract separates a fast-moving (prealbumin) thermolabile factor chromatographically identical with group C.

  6. 6.

    Extracts of foetal membrane (chorion) contain thermolabile factors corresponding chromatographically with groups B, C and D.

  7. 7.

    The three main coagulative factors of chorion extract have been isolated in active form by large scale chromatography on DEAB cellulose.

  8. 8.

    The nitrogen content of the factors has been found to be significantly lower than in most proteins.

  9. 9.

    The factors have been examined by starch gel electrophoresis.

  10. 10.

    The factors do not coagulate fibrinogen and, therefore, do not contain thrombin.

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Authors and Affiliations

  1. Departments of Biochemistry and Experimental Medicine, Trinity College, Dublin

    W. A. Boggust, D. J. O’Brien, R. A. Q. O’Meara & R. D. Thornes

Authors
  1. W. A. Boggust
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  2. D. J. O’Brien
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  3. R. A. Q. O’Meara
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  4. R. D. Thornes
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Boggust, W.A., O’Brien, D.J., O’Meara, R.A.Q. et al. The coagulative factors of normal human and human cancer tissue. Ir J Med Sci 38, 131–144 (1963). https://doi.org/10.1007/BF02948555

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  • DOI: https://doi.org/10.1007/BF02948555

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