Abstract
Primary mucosa-associated lymphoid tissue (MALT) type lymphoma arising in the oral cavity is rare. We examined histopathologic, immunohistological and genotypic findings of seven cases of intraoral MALT lymphoma using formalin-fixed paraffin-embedded tissues. Histologically, two variants have been delineated. (i) In four cases of minor salivary gland type, the lymphoid follicles were surrounded by centrocyte-like (CCL) cells with occasional follicular colonization. The CCL cells invaded the residual salivary gland duct resulting in a lymphoepithelial lesion. CCL cells frequently showed plasmacytic differentiation. (ii) In three cases of follicular growth type, the lesion was characterized by follicular growth pattern resulting from prominent follicular colonization. CCL cells showed minimal plasma cell differentiation. There was no residual epithelial component detected even by cytokeratin immunostaining. There were no Epstein-Barr virus-encoded small RNA-positive cells detected byin situ hybridization. API2-MALT1 fusion transcript does not appear to be associated with either histological variant of primary intraoral MALT lymphoma.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Epstein JB, Epstein JD, Le ND, Gorsky M: Characterization of oral and paraoral malignant lymphoma: a population-based review of 361 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 92:519–525, 2001
Takahashi H, Fujita S, Okabe H, Tsuda N, Tezuka F: Immunophenotypic analysis of extranodal non-Hodgkin’s lymphomas in oral cavity. Pathol Res Pract 189:300–311, 1993
Solomides CC, Miller AS, Christman RA, Talwar J, Simpkins H. Lymphomas of the oral cavity: Histology, immunologic type, and incidence of Epstein-Barr virus infection. Hum Pathol 33:153–157, 2002
Odell EW, Lombardi T, Shirlaw PJ, White CAM: Minor salivary gland hyalinization and amyloidosis in low-grade lymphoma of MALT. J Oral Pathol Med 27:229–232, 1998
Sakabe H, Bamba M, Nomura K, Kitamura S, Segawa H, Yasui H, Inoue T, Taniwaki M, Fujiyama Y, Bamba T: MALT lymphoma at the base of the tongue developing without any background of immunodeficiency or autoimmune disease. Leuk Lymphoma 44:875–878, 2003
Honda K, Kusama H, Takagi S, Sekine S, Noguchi M, Chiba H: Diagnosis of intra-oral MALT lymphoma using seminested polymerase chain reaction. Br J Oral Maxillofac Surg 42:28–32, 2004
Sakuma H, Okabe M, Yokoi M, Eimoto T, Inagaki H: Spontaneous regression of intraoral mucosa-associated lymphoid tissue lymphoma: molecular study of a case. Pathol Intern 56:331–335, 2006
Kojima M, Sugihara S, Iijima M, Ono T, Yoshizumi T, Masawa N: Marginal zone B-cell lymphoma of minor salivary gland representing tumor-forming amyloidosis of the oral cavity. A case report. J Oral Pathol Med 35:314–316, 2006
Inagaki H, Chan JKC, Ng JWM, Okabe M, Yoshino T, Okamoto M, Ogawa H, Matsushita H, Yokose T, Matsuno Y, Nakamura N, Nagasaka T, Ueda R, Eimoto T, Nakamura S: Primary thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathological and molecular features. Am J Pathol 160:1435–1443, 2002
Isaacson PG, Norton AJ: Extranodal lymphomas. Churchill Livingstone, Edinburgh, 1994
Chan ALC, Chan JKC. Haematolymphoid tumors. In: Pathology and genetics of tumours of head and neck. (Eds: Barnes L, Evenson JW, Reichart P, Sidransky D), IARCPress, Lyon, 2005, pp 199–205
Isaacson PG, Wotherspoon AC, Diss T, Pan L: Follicular colonization of B-cell lymphoma of mucosa-associated lymphoid tissue. Am J Surg Pathol 15:819–828, 1991
Kojima M, Yamanaka S, Yoshida T, Shimizu K, Murayama K, Ohno Y, Itoh H, Motoori T, Masawa N, Nakamura S: Histological variety of floral variant of follicular lymphoma. A report of 13 Japanese cases. APMIS 114:626–632, 2006
Lai R, Weiss LM, Chang KL, Arber DA: Frequency of CD43 expression in non-Hodgkin lymphoma. A survey of 742 cases and further characterization of rare CD43+ follicular lymphoma. Am J Clin Pathol 111:488–494, 1999
Wang T, Lasota J, Hanau CA, Miettinen M: Bcl-2 oncoprotein is widespread in lymphoid tissue and lymphoma but its differential expression in benign versus malignant follicles and monocytoid B-cell proliferation is of diagnostic value. APMIS 103: 655–662, 1995
Isaacson PG, Du M-Q: Gastrointestinal lymphoma: where morphology meets molecular biology. J Pathol 205:255–274, 2005
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kojima, M., Nakamura, N., Shimizu, K. et al. Histopathological variation of primary mucosa-associated lymphoid tissue lymphoma of the oral cavity. Pathol. Oncol. Res. 13, 345–349 (2007). https://doi.org/10.1007/BF02940315
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02940315