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Wirkungen von Kohlenmonoxid auf das kardiovaskuläre System

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Zusammenfassung

Wirkungen einer Kohlenmonoxidhypoxie bis zu 25% Carboxyhämoglobin auf das kardiovaskuläre System werden beschrieben. Dabei wird von bekannten Wirkprinzipien, insbesondere der CO-Bindung an Hämoproteine, des HALDANE-Effektes und von Änderungen im Energiehaushalt aufgrund der Tendenz zum anaeroben Stoffwechsel ausgegangen. Empfindlich reagieren ältere Personen, Menschen mit einer Vorschädigung des Herzkreislaufsystems und der Fetus, darauf weisen morphologische, funktionelle und biochemische Veränderungen hin. Bei Exponierten imponieren Kompensations- und Adaptationsreaktionen, die aber unter gewissen Voraussetzungen mit Regressivelementen verbunden sein können. Die Aussage vorliegender epidemiologischer Daten ist gering.

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  1. Institut für Industrietoxikologie der Martin-Luther-Universität, Franzosenweg 1 a, D-06112, Halle/Saale

    Dieter Pankow & Peter Hoffmann

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  1. Dieter Pankow
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  2. Peter Hoffmann
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Pankow, D., Hoffmann, P. Wirkungen von Kohlenmonoxid auf das kardiovaskuläre System. UWSF - Z. Umweltchem. Ökotox. 5, 320–326 (1993). https://doi.org/10.1007/BF02937981

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