Abstract
Among the various molecular events that have been proposed to contribute to the mechanisms of long-term potentiation (LTP), one of the most cited possibilities has been the activation of protein kinase C (PKC). Here we review various aspects of the cellular actions of PKC activationa and inhibition, with special emphasis on the effects of the kinase on synaptic transmission and theN-methyl-D-aspartate (NMDA) and non-NMDA receptor-mediated components of synaptic responses. We discuss the implications of these effects for interpretations of the role of PKC in the mechanisms of LTP induction and maintenance.
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Muller, D., Buchs, PA., Stoppini, L. et al. Long-term potentiation, protein kinase C, and glutamate receptors. Mol Neurobiol 5, 277–288 (1991). https://doi.org/10.1007/BF02935551
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DOI: https://doi.org/10.1007/BF02935551