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Role of the growth-associated protein B-50/GAP-43 in neuronal plasticity

  • Basic Molecular Aspects of Synaptic Plasticity
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Abstract

The neuronal phosphoprotein B-50/GAP-43 has been implicated in neuritogenesis during developmental stages of the nervous system and in regenerative processes and neuronal plasticity in the adult. The protein appears to be a member of a family of acidic substrates of protein kinase C (PKC) that bind calmodulin at low calcium concentrations. Two of these substrates, B-50 and neurogranin, share the primary sequence coding for the phospho- and calmodulin-binding sites and might exert similar functions in axonal and dendritic processes, respectively. In the adult brain, B-50 is exclusively located at the presynaptic membrane. During neuritogenesis in cell culture, the protein is translocated to the growth cones, i.e., into the filopodia. In view of many positive correlations between B-50 expression and neurite outgrowth and the specific localization of B-50, a role in growth cone function has been proposed. Its phosphorylation state may regulate the local intracellular free calmodulin and calcium concentrations or vice versa. Both views link the B-50 protein to processes of signal transduction and transmitter release.

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  1. Rudolf Magnus Institute, Institute of Molecular Biology and Medical Biotechnology, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands

    W. H. Gispen, H. B. Nielander, P. N. E. De Graan, A. B. Oestreicher, L. H. Schrama & P. Schotman

  2. Laboratory for Physiological Chemistry, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands

    W. H. Gispen, H. B. Nielander, P. N. E. De Graan, A. B. Oestreicher, L. H. Schrama & P. Schotman

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Gispen, W.H., Nielander, H.B., De Graan, P.N.E. et al. Role of the growth-associated protein B-50/GAP-43 in neuronal plasticity. Mol Neurobiol 5, 61–85 (1991). https://doi.org/10.1007/BF02935540

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