Skip to main content
SpringerLink
Log in

Multiple early esophageal cancers arising from Barrett's esophagus, and a review of cases of early adenocarcinoma in Barrett's esophagus in Japan

  • Case Report
  • Published:
Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

A case of early esophageal adenocarcinoma arising in Barrett's esophagus is reported. Many cases of Barrett's esophagus, which is considered a premalignant condition, have been reported in Western countries, but few cases have been reported in Japan. The patient, a 53-year-old man with nausea and vomiting, was a drinker (four glasses wine/day for about 30 years), but did not smoke. He had had a hiatal hernia of the esophagus. Since endoscopic biopsies demonstrated an early adenocarcinoma in Barrett's esophagus, subtotal esophagectomy was performed. In the resected esophageal material, Barrett's esophagus was seen to extend for 12 cm. In addition to the cancer detected preoperatively as a 0-IIc lesion (1.5 cm in diameter), a 0-IIb lesion (1.5 cm in diameter) was also detected in the post-operative survey. Both lesions were well differentiated adenocarcinoma that had invaded only into the lamina propria mucosa. The 23 cases of early adenocarcinoma in Barrett's esophagus that have been reported in Japan were reviewed, and it was learned that the present case is the second of multiple early cancer arising in Barrett's esophagus so far reported in Japan.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bernstein IT, Kruse P, Andersen IB, et al. Barrett's oesophagus. Dig Dis 1994;12:98–105.

    Article  PubMed  CAS  Google Scholar 

  2. Skinner DB, Walther BC, Riddell RH, et al. Barrett's esophagus—comparison of benign and malignant cases. Ann Surg 1983;198:554–566.

    Article  PubMed  CAS  Google Scholar 

  3. Hameeteman W, Tytgat GNJ, Houthoff HJ, et al. Barretts esophagus; development of dysplasia and adenocarcinoma. Gastroenterology 1989;96:1249–1256.

    PubMed  CAS  Google Scholar 

  4. Hawe A, Payne WS, Weiland LH, et al. Adenocarcinoma in the columnar epithelial lined lower (Barrett) oesophagus. Thorax 1973;28:511–514.

    PubMed  CAS  Google Scholar 

  5. McDonald GB, Brand DL, Thorning DR. Multiple adenocarcinoma neoplasms arising in columnar-lined (Barrett's) esophagus. Gastroenterology 1977;72:1317–1321.

    PubMed  CAS  Google Scholar 

  6. Saubier EC, Gouillat C, Samaniego C, et al. Adenocarcinoma in columnar-lined Barrett's esophagus. Analysis of 13 esophagectomies. Am J Surg 1985;150:365–369.

    Article  PubMed  CAS  Google Scholar 

  7. Haggit RC. Barrett's esophagus, dysplasia, and adenocarcinoma. Hum Pathol 1994;25:982–993.

    Article  Google Scholar 

  8. Spechler SJ, Robbins AH, Rubins HB, et al. Adenocarcinoma and Barrett's esophagus—an overrated risk? Gastroenterology 1984;87:927–933.

    PubMed  CAS  Google Scholar 

  9. Menke-Pluymers MBE, Hop WCJ, Dees J, et al. Risk factors for the development of adenocarcinoma in columnar-lined (Barrett) esophagus. Cancer 1993;72:1155–1158.

    Article  PubMed  CAS  Google Scholar 

  10. Achkar JP, Post AB, Achkar E, et al. Risk of extraesophageal malignancy in patients with adenocarcinoma arising in Barrett's esophagus. Am J Gastroenterol 1995;90:39–43.

    PubMed  CAS  Google Scholar 

  11. Gray MR, Donnelly RJ, Kingsnorth AN, et al. The role of smoking and alcohol in metaplasia and cancer risk in Barrett's columnar lined oesophagus. Gut 1993;34:727–731.

    Article  PubMed  CAS  Google Scholar 

  12. Iftikhar SY, James PD, Steele RJC, et al. Length of Barrett's esophagus; an important factor in the development of dysplasia and adenocarcinoma. Gut 1992;295:476–480.

    Google Scholar 

  13. Miros M, Kelin P, Walker N. Only patients with dysplasia progress to adenocarcinoma in Barrett's oesophagus. Gut 1991;32:1441–1446.

    Article  PubMed  CAS  Google Scholar 

  14. Peters FT-M, Kleibeuker JH. Barrett's esophagus and carcinoma; recent insights into its development and possible prevention. Scand J Gastroenterol 1993;28(Suppl 200):59–64.

    Article  Google Scholar 

  15. Paull A, Trier JS, Dalton MD, et al. The histologic spectrum of Barrett's esophagus. N Engl J Med 1976;295:476–480.

    PubMed  CAS  Google Scholar 

  16. Sterns VA, Adkins RB, Ballinger JF, et al. Barrett's esophagus. Arch Surg 1984;119:563–567.

    Google Scholar 

  17. Nishi T, Makuuchi H, Machimura T, et al. A small adenocarcinoma arising in Barrett's esophagus—case report (in Japanese with English abstract). Endosc Digest 1995;7:557–563.

    Google Scholar 

  18. Hamada K, Tateno M, Yoshiki T, et al. Adenocarcinoma originating from Barrett's esophagus—report of a case (in Japanese with English abstract). Stomach and Intestine 1980;15:1017–1021.

    Google Scholar 

  19. Oshima A, Ando N, Suguro Y, et al. Early carcinoma existing in Barrett's esophagus—report of a case (in Japanese with English abstract). Stomach and Intestine 1983;18:72–75.

    Google Scholar 

  20. Kamio M, Miyamoto Y, Sudoh H, et al. A case of early cancer arising in Barrett's esophagus (in Japanese). Jpn J Gastroenterol Surg 1983;211:1153.

    Google Scholar 

  21. Yuasa K, Sekiguchi T, Kunugi S, et al. A case of early adenocarcinoma seen in Barrett's esophagus (in Japanese with English abstract). Progr Dig Endosc 1983;23:170–173.

    Google Scholar 

  22. Nagano M, Yamaki G, Ito T, et al. A case of early adenocarcinoma existing in Barrett's esophagus (in Japanese with English abstract). Progr Dig Endosc 1985;26:215–218.

    Google Scholar 

  23. Shimazaki Y, Saitoh M, Kurata F, et al. A case of adenocarcinoma in Barrett's esophagus (in Japanese). Gastroenterol Endosc 1985;27:1416.

    Google Scholar 

  24. Nagai N. A case of early Barrett's cancer pointed out during endoscopic embolization therapy for esophageal varices (in Japanese). Endosc Forum Dig 1987;22:1133–1136.

    Google Scholar 

  25. Abe M, Aoyama N, Noguchi Y, et al. A case of early adenocarcinoma arising in Barrett's esophagus (in Japanese). Jpn J Gastroenterol 1988;85:1726.

    Google Scholar 

  26. Negoto Y, Tou Y, Nishido H, et al. A case of early adenocarcinoma with intraepithelial spread on Barrett esophagus (in Japanese). Jpn J Gastroenterol Surg 1983;22:1133–1136.

    Google Scholar 

  27. Imada T, Rino Y, Abe M, et al. Early carcinoma existing in Barrett's esophagus; report of a case (in Japanese with English abstract). Yokohama Igaku (Yokohama Med J) 1989;40:391–396.

    Google Scholar 

  28. Horanoguchi Y, Wada N, Masago M, et al. A case of early adenocarcinoma arising in Barrett's esophagus (in Japanese). Jpn J Gastroenterol 1989;86:2646.

    Google Scholar 

  29. Iwasaki Y, Yoshida M, Yoshikawa T, et al. Barrett's esophagus associated with chronic ulcer and multiple early cancers; report of a case (in Japanese with English abstract). Stomach and Intestine 1990;25:433–437.

    Google Scholar 

  30. Konishi M, Kato H, Tachimori Y, et al. A case of adenocarcinoma in Barrett-like esophagus after total resection of the gastric remnant (in Japanese with English abstract). Jpn J Gastroenterol Surg 1991;24:2565–2569.

    Google Scholar 

  31. Masuda T, Mizutani M, Miki T, et al. A case of a Barrett's esophageal carcinoma (in Japanese with English abstract). Jpn Cancer Clin 1991;37:1536–1542.

    Google Scholar 

  32. Kito Y, Chigira H, Katoh T, et al. A case of early esophageal adenocarcinoma arising in Barrett's epithelium (in Japanese with English abstract). Jpn J Gastroenterol 1992;89:2614–2618.

    CAS  Google Scholar 

  33. Koori T, Atsumi S, Ise H, et al. A case of early adenocarcinoma existing in Barrett's esophagus (in Japanese). Gastroenterol Endosc 1993;35:1321–1326.

    Google Scholar 

  34. Tamai S, Tarao K, Koizumi H, et al. Superficial adenocarcinoma arising from Barrett's esophagus; report of a case (in Japanese with English abstract). Stomach and Intestine 1993;28:225–230.

    Google Scholar 

  35. Hasegawa N, Konishi K, Koshi K, et al. A case of early adenocarcinoma arising in Barrett's esophagus (in Japanese with English abstract). Stomach and Intestine 1993;5:119–122.

    Google Scholar 

  36. Hashimoto R, Kaneko H, Miyachi K, et al. A case of early adenocarcinoma arising in Barrett's esophagus (in Japanese). Jpn J Gastroenterol 1993;89:782.

    Google Scholar 

  37. Naef AP, Savary M, Ozzello L, et al. Columnar-lined lower esophagus. An acquired lesion with malignant predisposition. Report on 140 cases of Barrett's esophagus with 12 adenocarcinomas. J Thorac Cardiovasc Surg 1975;70:826–835.

    PubMed  CAS  Google Scholar 

  38. Paraf F, Flejou JF, Pignon JP, et al. Surgical pathology of adenocarcinoma arising in Barrett's esophagus—analysis of 67 cases. Am J Surg Pathol 1995;9:183–191.

    Article  Google Scholar 

  39. Endoh M. Barrett's esophagus (in Japanese with English abstract). Stomach and Intestine 1990;25:391–397.

    Google Scholar 

  40. Sawada R, Ragayama M, Ishikawa T, et al. A case of superficial adenocarcinoma arising in the Barrett's esophagus (in Japanese with English abstract). J Jpn Soc Clin Surg 1991;52(7):1532–1537.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan

    Tomoko Itatsu, Hiroto Miwa, Toshio Murai, Takeshi Terai, Ryuichi Ohkura, Shigeru Sorimachi, Sung Wook Yang, Tatsuo Ogihara, Sumio Watanabe & Nobuhiro Sato

  2. Department of Pathology, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan

    Shu Hirai

Authors
  1. Tomoko Itatsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hiroto Miwa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Toshio Murai
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Takeshi Terai
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ryuichi Ohkura
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shigeru Sorimachi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Sung Wook Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Tatsuo Ogihara
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Sumio Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Shu Hirai
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Nobuhiro Sato
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Itatsu, T., Miwa, H., Murai, T. et al. Multiple early esophageal cancers arising from Barrett's esophagus, and a review of cases of early adenocarcinoma in Barrett's esophagus in Japan. J Gastroenterol 32, 389–395 (1997). https://doi.org/10.1007/BF02934498

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02934498

Key words

Search

Navigation