Abstract
We conducted a case-control study to examine the association ofHelicobacter pylori infection as a risk factor in gastric cancer in the Japanese population. Serum IgG antibodies forHelicobacter pylori were determined in 55 consecutive patients with gastric cancer and in 75 age- and sex-matched mass survey subjects and 57 age- and sex-matched cancer-free patients with conditions considered at a high risk for development of gastric cancer (precancerous condition). We examined the histology in all subjects and particular focus was placed on the extent ofHelicobacter pylori-associated gastritis. The seroprevalence ofHelicobacter pylori in gastric cancer patients (82%) and those with a precancerous condition (89%) was significantly higher (P<0.005) than that in the mass survey subjects (60%). Positive relative risk associations were found for patients with gastric cancer (odds ratio, 3, with 95% confidence intervals of 1.69–5.33) and those with a precancerous condition (odds ratio, 5.66, with 95% confidence intervals 2.66–12.03). Significant differences were found when comparisons were made among the case-control groups who wereH. pylori-positive and had inflammatory cell infiltration (P=0.0127). The characteristics ofHelicobacter pylori in histologically examined gastric mucosa showed differences betweenHelicobacter pylori-infected and uninfected persons in all groups. However, for none of these groups was there a significant difference between background mucosa forHelicobacter pylori-infected persons with or without gastric cancer.Helicobacter pylori seroprevalence is strongly associated with an increased risk of gastric cancer and with a precancerous condition; histological investigation did not define additional factors that might be associated with increased cancer risk.
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Barreto-Zuñiga, R., Maruyama, M., Kato, Y. et al. Significance ofHelicobacter pylori infection as a risk factor in gastric cancer: Serological and histological studies. J Gastroenterol 32, 289–294 (1997). https://doi.org/10.1007/BF02934482
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DOI: https://doi.org/10.1007/BF02934482