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Adjacent location of thebac gene and two-component regulatory system genes within the putativeStreptococcus agalactiae pathogenicity island

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Abstract

A chromosomal DNA fragment of 8992 bp in size that has not been previously identified inStreptococcus agalactiae, was cloned and sequenced from strain 98-D60C. In particular, this 8992-bp fragment contained genes homologous to the sensor histidine kinase gene and the DNA-binding response-regulator gene ofStreptococcus pneumoniae, andS. agalactiae bac gene. Structural and genetic features of the 8992-bp fragment were highly similar to those specific for bacterial pathogenicity islands. Analysis of epidemiologically unrelatedS. agalactiae strains revealed that this fragment was present only inbac gene-positive strains. The possible origin of the 8992-bp fragment inS. agalactiae and its significance for molecular mechanisms of “bacteria-host” interactions are discussed.

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Authors and Affiliations

  1. Institute of Experimental Medicine, Academy of Medical Sciences, 197376, Saint Petersburg, Russia

    A. Dmitriev & A. Totolian

  2. Beijing Children’s Hospital Affiliated to Capital University of Medical Sciences, 100045, Beijing, P.R.China

    Y. H. Yang & A. D. Shen

Authors
  1. A. Dmitriev
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  2. Y. H. Yang
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  3. A. D. Shen
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  4. A. Totolian
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Correspondence to A. Dmitriev.

Additional information

This study was supported by theMinistry of Science and Technology (P.R. China), theRegional Public Foundation of Russian Medicine Support, and theRussian Foundation for Basic Research grant RFBR 06-04-48949.

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Dmitriev, A., Yang, Y.H., Shen, A.D. et al. Adjacent location of thebac gene and two-component regulatory system genes within the putativeStreptococcus agalactiae pathogenicity island. Folia Microbiol 51, 229–235 (2006). https://doi.org/10.1007/BF02932127

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  • DOI: https://doi.org/10.1007/BF02932127

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