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Levels of apolipoprotein A-II in cerebrospinal fluid in patients with neuroborreliosis are associated with lipophagocytosis

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Abstract

Levels of most of the examined proteins in cerebrospinal fluid (CSF) of 107 patients with neuroborreliosis were associated with cytological findings, the status of hematoencephalic barrier as evaluated byQ alb (cerebrospinal fluid to serum quotient) and the intrathecal synthesis of immunoglobulins. Cytological findings consisted of normal cytology, or both oligocytosis and pleocytosis of monocytes or lymphocytes. The lipophagic elements were present in 20 % of samples. Concentrations of apolipoproteins A-I and A-II in the CSF were correlated with the concentration of albumin without regard to the CSF cytology. The levels of apolipoprotein B were increased only in samples with lymphocytic pleocytosis andQ alb > 7.4. The presence of lipophages in the CSF was significantly associated with the CSF concentration of apolipoprotein A-II.

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Abbreviations

Apo:

apolipoproteins

BBB:

blood-brain barrier

CNS:

central nervous system

CSF:

cerebrospinal fluid

Ig:

immunoglobulins

Ly-O:

lymphocytic oligocytosis

Ly-P:

lymphocytic pleocytosis

Mo-O:

monocytic oligocytosis

Mo-P:

monocytic pleocytosis

Q alb :

CSF albumin-to-serum albumin quotient

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Authors and Affiliations

  1. Department of Clinical Biochemistry, Hospital Homolka, 150 30, Prague, Czechia

    L. Táborský, P. Adam, O. Sobek, J. Dvořáková & L. Dubská

  2. Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 20, Prague, Czechia

    M. Dostál

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  1. L. Táborský
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  2. P. Adam
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  3. O. Sobek
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  4. M. Dostál
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  5. J. Dvořáková
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  6. L. Dubská
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Táborský, L., Adam, P., Sobek, O. et al. Levels of apolipoprotein A-II in cerebrospinal fluid in patients with neuroborreliosis are associated with lipophagocytosis. Folia Microbiol 48, 849–855 (2003). https://doi.org/10.1007/BF02931523

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  • DOI: https://doi.org/10.1007/BF02931523

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