Abstract
Almost all nutrients in the diet play a crucial role in maintaining an “optimal” immune response, and both insufficient and excessive intakes can have negative consequences on the immune status and susceptibility to a variety of pathogens. We summarize the evidence for the importance of two micronutrients, selenium and zinc, and describe the mechanisms through which they affect the immune status and other physiological functions. As a constituent of selenoproteins, selenium is needed for the proper functioning of neutrophils, macrophages, NK cells, T lymphocytes and some other immune mechanisms. Elevated selenium intake may be associated with reduced cancer risk and may alleviate other pathological conditions including oxidative stress and inflammation. Selenium appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS. It is required for sperm motility and may reduce the risk of miscarriage. Selenium deficiency has been linked to adverse mood states and some findings suggest that selenium deficiency may be a risk factor in cardiovascular diseases. Zinc is required as a catalytic, structural and regulatory ion for enzymes, proteins and transcription factors, and is thus a key trace element in many homeostatic mechanisms of the body, including immune responses. Low zinc ion bioavailability results in limited immunoresistance to infection in aging. Physiological supplementation of zinc for 1–2 months restores immune responses, reduces the incidence of infections and prolongs survival. However, in every single individual zinc supplementation of food should be adjusted to the particular zinc status in views of the great variability in habitat conditions, health status and dietary requirements.
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Abbreviations
- AIDS:
-
acquired immunodeficiency syndrome
- CTL:
-
cytotoxic T lymphocytes
- GPx:
-
glutathione peroxidases
- HDL:
-
high-density lipoproteins
- HIV:
-
human immunodeficiency virus
- IFN-γ:
-
interferon γ
- IL:
-
interleukin
- IS:
-
immune system
- NF-κB:
-
nuclear factor κB
- NK:
-
natural killer (cells)
- oxLDL:
-
oxidized low-density lipoproteins
- PGI:
-
vasodilatation-active prostacyclin
- ROI:
-
reactive oxygen intermediate
- AT:
-
active form of thymulin
- TT:
-
total serum thymulin
- TDR:
-
thioredoxin reductase
- TH1, TH2, TH3 (cells):
-
helper T lymphocytes
- TNF:
-
tumor necrosis factor
References
Allan C.B., Lacourciere G.M., Stadtman T.C.: Responsiveness of selenoproteins to dietary selenium.Ann.Rev.Nutr. 19, 1–16 (1999).
Barrington J.W., Taylor M., Smith S., Bowen-Simpkins P.: Selenium and recurrent miscarriage.Gynecology 17, 199–200 (1997).
Baum M.K., Shor-Posner G., Lai S., Campa A.M., Trapido E.: High risk of HIV-related mortality is associated with selenium deficiency.J.Acquir. Immune Defic.Syndr. 15, 370–374 (1997).
Benton D., Cook R.: Selenium supplementation improves mood in a double-blind crossover trial.Biol.Psychiatry 29, 1092–1098 (1991).
Combs G.F., Gray W.P.: Chemopreventive agents: selenium.Pharmacol.Ther. 79, 179–192 (1998).
Cuajungco M.P., Lees G.J.: Zine and Alzheimer’s disease: is there a direct link?Brain Res.Rev. 23, 219–236 (1997).
El-Bayoumy K.: The protective role of selenium on genetic damage and on cancer.Mutat.Res. 475, 123–139 (2001).
Field C.J. Johnson I.R., Schley P.D.: Nutrients and their role in host resistance to infection.J.Leukoc.Biol. 71, 16–32 (2002).
Finley J.W., Penland J.G.: Adequacy or deprivation of dietary selenium in healthy men — clinical and psychological findings.J.Trace Elem.Exp.Med. 11, 11–27 (1998).
Fosmire G.J.: Zinc toxicity.Am.J.Clin.Nutr. 51, 225–227 (2000).
Fraker P.J., Telford W.G.: A reappraisal of the role of zinc in life and death decisions of cells.Proc.Soc.Exp.Biol.Med. 215, 229–236 (1997).
Fraker P.J., King L.E., Laakko T., Vollmer T.L.: The dynamic link between the integrity of the immune system and zinc status.J.Nutr. 130, 1399S-406S (2000).
Gazdik F., Horváthova M., Gazdikova K., Jahnova E.: The influence of selenium supplementation on the immunity of corticoid-dependent asthmatics.Bratisl.Lek.Listy 103, 17–21 (2002).
Hawkes W.C., Hornbostel L.: Effect of dietary selenium on mood in healthy men living in a metabolic research unit.Biol.Psychiatry 39, 121–128 (1996).
Jahnová E., Horvathová M., Gazdík P., Weissová S.: Effects of selenium supplementation on expression of adhesion molecules in corticoid-dependent asthmatics.Bratisl.Lek.Listy 103, 12–16 (2002).
Jiang C., Jiang W., Ip C., Ganther H., Lu J.: Selenium-induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake.Mol.Carcinogen. 26, 213–225 (1999).
Johnson V.J., Tsunoda M., Sharma R.P.: Increased production of proinflammatory cytokines by mouse macrophages following oral exposure to sodium selenite but not to seleno-l-methionine.Arch.Environ.Contam.Toxicol. 39, 243–250 (2000).
Kadrabová J., Madarič A., Kovačiková Z., Podivinsky F., Gazdík F.: Selenium status is decreased in patients with intrinsic asthma.Biol.Trace Elem.Res. 52, 241–248 (1996).
Kiremidjian-Schumacher I., Roy M., Wishe H.I., Cohen M.W., Stocky G.: Supplementation with selenium and human immune cell functions.Biol.Trace Elem.Res. 41, 115–127 (1994).
Longnecker M.P., Taylor O.A. Levander S.M., Stram D.O., Howe M., Patterson K.Y.: Selenium in diet, blood and toenails in relation to human health in a seleniferous area.Am.J.Clin.Nutr. 53, 1288–1294 (1991).
Madarič A., Kadrabová J., Ginter E.: Selenium concentration in plasma and erythrocytes in a healthy Slovak population.J.Trace Elem.Electrol.Health Dis. 8, 43–47 (1994).
McKenzie R.C., Rafferty T.C., Beckett G.J.: Selenium: an essential element for immune function.Immunol.Today 19, 342–345 (1998).
Meydani S.N., Beharka A.A.: Vitamin E and immune response in the aged.Bibl.Nutr.Dieta 55, 148–158 (2001).
Mocchegiani E., Muzzioli M.: Therapeutic application of zinc in human immune deficiency virus against opportunistic infections.J.Nutr. 130, 1424S-1431S (2000).
Mocchegiani E., Muzzioli M., Giacconi R: Zinc and immunoresistance to infection in ageing: new biological tools.Trends Immunol.Biol.Sci. 21, 205–258 (2000a).
Mocchegiani E., Giacconi R., Muzzioli M., Cipriano C.: Zinc, infections and immunosenescence.Mech.Ageing Develop. 121, 21–35 (2000b).
Neve J.: Selenium as a risk factor for cardiovascular diseases.J.Cardiovasc.Risk 3, 42–47 (1996).
Oldereid N.B., Thomassen Y., Purvis K.: Selenium in human male reproductive organs.Human Reprod. 13, 2172–2176 (1998).
Pepersack T., Rotsaert P., Benoit E., Willems D., Fuss M., Bourdoux P., Duchateau J.: Prevalence of zinc deficiency and its clinical relevance among hospitalised elderly.Arch.Gerontol.Geriat. 33, 243–252 (2001).
Peretz A., Neve J., Duchateau J.P., Famaey J.P.: Adjuvant treatment of recent onset rheumatoid arthritis by selenium supplementation: preliminary observations.Brit.J.Rheumatol. 31, 281–286 (1992).
Prasad A.S.: Zinc and immunity.Mol.Cell.Biol.Chem. 188, 63–69 (1998a).
Prasad A.S.: Effects of zinc deficiency on TH1 and TH2 cytokine shifts.J.Infect.Dis. 182 (Suppl. 1), S62-S68 (1998b).
Prasad A.S., Fitzgerald J.E., Bao B., Beck E.W., Chandrasekar P.H.: Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial.Ann.Intern.Med. 133, 245–252 (2000).
Rayman M.P.: The importance of selenium to human health.Lancet 356, 233–241 (2000).
Rovenský J., Švík K., Stančíková M., Ištok R., Ebringer L., Ferenčik M.: Treatment of experimental adjuvant arthritis with the combination of methotrexate and lyophilizedEnterococcus faecium enriched with organic selenium.Folia Microbiol. 47, 573–578 (2002).
Roy S.K., Tomkins A.M., Haider R., Behren R.H., Akramuzzaman S.M., Mahalanabis D., Fuchs G.J.: Impact of zinc supplementation on subsequent growth and morbidity in Bangladeshi children with acute diarrhea.Eur.J.Clin.Nutr. 53, 529–534 (1999).
Sazawal S., Black R.E., Jalla S., Mazumdar S., Sinha A., Bhan M.K.: Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind controlled trial.Pediatrics 102, 1–5 (1998).
Schewe T.: Molecular actions of ebselen — an antiin flammatory antioxidant.Gen.Pharmacol. 26, 1153–1169 (1995).
Scott R., MacPherson A.: Selenium supplementation in subfertile human males.Brit.J.Urol. 82, 76–80 (1998).
Shaheen S.O., Sterne J.A.C., Thompson R.L.: Dietary antioxidants and asthma in adults.Eur.Resp.J. 14 (Suppl. 30), 141 (1998).
Shankar A.H., Prasad A.S.: Zinc and immune function: the biological basis of altered resistance to infections.Am.J.Clin.Nutr. 68, 447S-4463S (1998).
Turner R.B., Cetnarowski W.E.: Effect of treatment with zinc gluconate or zinc acetate on experimental and natural colds.Clin. Infect.Dis. 31, 1202–1208 (2000).
Wendel A., Kuesters S., Tiegs G.: Ebselen — anin vivo immune response modifier.Biomed.Environ.Sci. 10, 239–253 (1997).
Yoshizawa K., Wilier W.C., Morris S.J., Stampfer M.J., Spiegelman D., Rimm E.B., Giovanucci E.: Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer.J.Nat.Cancer Inst. 90, 1219–1224 (1998).
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Ferenčík, M., Ebringer, L. Modulatory effects of selenium and zinc on the immune system. Folia Microbiol 48, 417–426 (2003). https://doi.org/10.1007/BF02931378
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DOI: https://doi.org/10.1007/BF02931378