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Evaluation of O2 and CO2 transfer coefficients in a locally integrated tubular hollow fiber bioreactor

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Abstract

We have studied the transfer coefficients for O2 transport to and CO2 removal from a model cell-free system using microporous hydrophobic hollow fibers axially placed along a tubular bioreactor for ethanol production with immobilized yeast in the shell. In this locally integrated bioreactor, O2 and CO2 transfer rates depend strongly on the shell side liquid flow rate; O2 flow rate in the fiber bore influences O2 transport only at very low flow rates. Diffusion of CO2 does not affect O2 transport. Local and overall O2 and CO2 transfer coefficients have been determined for a wide range of Reynolds Numbers. The efficiency of such transfers has been demonstrated for alcohol fermentation.

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Author notes

  1. G. T. Frank

    Present address: Merck Sharp and Dohme Research Laboratories, 07065, Rahway, NJ

Authors and Affiliations

  1. Department of Chemistry and Chemical Engineering, Stevens Institute of Technology, 07030, Castle Point, Hoboken, NJ

    W. Kang, R. Shukla, G. T. Frank & K. K. Sirkar

Authors
  1. W. Kang
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  2. R. Shukla
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  3. G. T. Frank
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  4. K. K. Sirkar
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Kang, W., Shukla, R., Frank, G.T. et al. Evaluation of O2 and CO2 transfer coefficients in a locally integrated tubular hollow fiber bioreactor. Appl Biochem Biotechnol 18, 35–51 (1988). https://doi.org/10.1007/BF02930816

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  • DOI: https://doi.org/10.1007/BF02930816

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