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Neutral endopeptidase/CD10 andAminopeptidase N/CD13 gene expression as a prognostic factor in non-small cell lung cancer

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Abstract

Objectives: Neutral endopeptidase modulates the growth of lung cancer, while aminopeptidase N degrades the extracellular matrix and is involved in cell motility. We studied the metastasis mechanism to detect novel metastasis-associated molecules and to evaluate them for clinical application.Methods: We studied the relationship between the expression of neutral endopeptidase and aminopeptidase N by quantitative reverse transcript-polymerase chain reaction analysis in 132 patients with non-small cell lung cancer undergoing radical surgery from 1991 to 1996.Results: Patients with neutral endopeptidase-positive and aminopeptidase N-negative tumors were defined as group A, those with neutral endopeptidase-positive and aminopeptidase N-positive or neutral endopeptidase-negative and aminopeptidase N-negative tumors as group B, and those with neutral endopeptidase-negative and aminopeptidase N-positive tumors as group C. The 5-year survival of group A patients (92.9%) was significantly better than that of group B patients (64.7%) and much better than that of group C patients (38.2%) (P=0.0011). Neutral endopeptidase and aminopeptidase N thus have statistically significant P in overall survival in Cox regression (P=0.019).Conclusion: Neutral endopeptidase and aminopeptidase N gene expressions are significant indicators of prognosis.

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Authors and Affiliations

  1. Department of Surgery, the Center for Adult Diseases of Osaka, Osaka, Japan

    Masahiko Higashiyama & Ken Kodama

  2. Department of Thoracic Surgery, Osaka Medical College, Osaka, Japan

    Takahiro Tokuhara, Shuichi Tachibana & Shinjiroh Sasaki

  3. Department of Thoracic Sirgery and Department V of Oncology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 13-3 Kamiyamacho, Kita-ku, 530-8480, Osaka, Japan

    Takahiro Tokuhara, Masashi Adachi, Hiroki Hashida, Hisao Ishida, Toshihiko Taki & Masayuki Miyake

Authors
  1. Takahiro Tokuhara
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  2. Masashi Adachi
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  3. Hiroki Hashida
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  4. Hisao Ishida
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  5. Toshihiko Taki
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  6. Masahiko Higashiyama
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  7. Ken Kodama
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  8. Shuichi Tachibana
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  9. Shinjiroh Sasaki
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  10. Masayuki Miyake
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Additional information

Read at the Fifty-Third Annual Meeting of The Japanese Association for Thoracic Surgery. Symposium. Oita, October 25–27, 2000.

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Tokuhara, T., Adachi, M., Hashida, H. et al. Neutral endopeptidase/CD10 andAminopeptidase N/CD13 gene expression as a prognostic factor in non-small cell lung cancer. Jpn J Thorac Caridovasc Surg 49, 489–496 (2001). https://doi.org/10.1007/BF02919543

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  • DOI: https://doi.org/10.1007/BF02919543

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