Abstract
Nearly two decades ago, it was observed that cells infected with herpes simplex virus (HSV) acquired an IgG Fc binding activity. The properties of the viral Fc receptor (FcR) have now been characterized by several laboratories. The Fc binding activity appears on the surface of the infected cell prior to formation of progeny virions. The FcR induced by HSV has been identified as the HSV glycoprotein, gE. When HSV gE forms a complex with a second HSV glycoprotein, gI, the receptor binds IgG with higher affinity. Varicella-zoster virus (VZV), which is closely related to HSV, has also been shown to induce an FcR. Like the HSV FcR, the FcR specified by VZV possesses characteristics common to viral glycoproteins. VZV encodes two glycoproteins, gpI and gpIV, which are the homologs of HSV gE and gI. The VZV glycoproteins have many properties common to cell surface receptors, including Olinked glycans and phosphorylation sites. However, extensive computer-assisted analyses of the amino acid sequences of VZV gpI and gpIV did not uncover regions of homology to the human cellular Fc receptors for IgG.
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References
Watkins JF: Adsorption of sensitized sheep erythrocytes to HeI a cells infected with herpes simplex virus. Nature 1964;202:1364–1365.
Watkins JF: The relationship of the herpes simplex haemadsorption phenomenon to the virus growth cycle. Virology 1965;26:746–753.
Yasuda J, Milgrom F: Hemadsorption by herpes simplex-infected cell cultures. Int Arch Allergy Appl Immunol 1968;33:151–170.
Sorkin E: On the cellular fixation of cytophilic antibody. Int Arch Allergy Appl Immunol 1964;25:129–144.
Howard JG, Benacerraf B: Properties of macrophage receptors for cytophilic antibody. Br J Exp Pathol 1966;47:193–200.
Westmoreland D, Watkins JF: The IgG receptor induced by herpes simplex virus: Studies using radioiodinated IgG. J Gen Virol 1974;24: 167–178.
McTaggart SP, Burns WH, White DO, Jackson DC: Fe receptors induced by herpes simplex virus. I. Biologic and biochemical properties. J Immunol 1978;121:726–730.
Baucke RB, Spear PG: Membrane proteins specified by herpes simplex viruses. V. Identification of an Fcbinding glycoprotein. J Virol 1979; 32:779–789.
Para MF, Baucke RB, Spear PG: Immunoglobulin G(Fc)-binding receptors on virions of herpes simplex virus type 1 and transfer of the receptors to the cell surface by infection. J Virol 1980;34:512–520.
Johnson DC, Feenstra V: Identification of a novel herpes simplex virus type 1-induced glycoprotein which complexes with gE and binds immunoglobulins J Virol 1987;61:2008–2216.
Johnson DC, Frame MC, Ligas MW, Cross AM, Stow ND: Herpes simllex virus immunoglobulin G Fc receptor activity depends on a complex of two viral glycoproteins, gE and gI. J Virol 1988;62:1347–1354.
Longnecker R, Chatteriee S, Whitley RJ, Roizman B: Identification of a herpes simplex virus 1 glycoprotein gene within a gene cluster dispensable for growth in cell culture. Proc Natl Acad Sci USA 1987;84: 4303–4307.
Hanke T, Graham FL, Lulitanond V, Johnson DC: Herpes simplex virus IgG Fc receptors induced using recombinant adenovirus vectors expressing glycoproteins E and I. Virology 1990;177:437–444.
Bell S, Crange M, Borysiewicz L, Minson T: Induction of immunoglobulin G Fc receptors by recombinant vaccinia viruses expressing glycoproteins E and I of herpes simplex virus type 1. J Virol 1990;64:2181–2186.
Edson CM, Hosler BA, Waters DJ; Varicella-zoster virus gpI and herpes simplex virus gE: Phosphorylation and Fc binding. Virology 1987;161: 599–602.
Ogata M, Shigeta S: Appearance of immunoglobulin G Fc receptor in cultured human cells infected with varicella-zoster virus. Infect Immun 1979;26:770–774.
Ishak R, Andiman WA, Tucker G: Absence of IgG Fc receptors on varicella-zoster virus-infected cells. J Med Virol 1984;13:261–267.
Gelb LD, Welinghoff WJ, Martin JH, Huang JJ: Varicella-zoster virus fails to induce immunoglobulin G Fc receptors in infected human cells. Proc Soc Exp Biol Med 1981;168: 228–232.
Davison AJ, Scott JE: The complete DNA sequence of varicella-zoster virus. J Virol 1986;67:1759–1816.
Litwin V, Sandor M, Grose C: Cell surface expression of the varicellazoster virus glycoproteins and Fc receptor. Virology 1990;178:263–272.
Anderson VL, Guyre PM, Whitin JC, Ryan DH, Looney RJ, Fanger MW: Monoclonal antibodies to Fc receptors for IgG on human mononuclear phagocytes. Antibody characterization and induction of superoxide production in a monocyte cell line. J Biol Chem 1986;134:465–470.
Fleit HB, Wright SD, Unkeless JC: Human neutrophil Fc receptor distribution and structure. Proc Natl Acad Sci USA 1982;79:3275–3279.
Vaughn M, Taylor M, Mohanakumar T: Characterization of human IgG Fc receptors. J Immunol 1985; 135:4059–4065.
Looney RJ, Abraham GN, Anderson CL: Human monocytes and U937 cells bear two distinct Fc receptors for IgG. J Immunol 1986; 135:1641–1647.
Smith CA, Davis T, Anderson D, Solam L, Beckman MP, Jerzy R, Dower SK, Cosman D, Goodwin RG. A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science 1990;248:1019–1023.
Montalvo EA, Parmley RT, Grose C: Structural analysis of the varicella-zoster virus gp98-pg62 complex: Post-translational modification addition of N-linked and O-linked oligosaccharide moieties. J Virol 1985; 53:761–770.
Montalvo EA, Grose C: Varicellazoster virus is selectively phosphorylated by a virus-induced protein kinase. Proc Natl Acad Sci USA 1986. 83:8967–8971.
Grose C, Jackson W, Traugh JA: Phosphorylation of varicella-zoster virus glycoprotein gpl by mammalian casein kinase II and casein kinase I. J Virol 1989;63:3912–3918.
Traugh JA: Approaches to examine the role of multiple serine protein kinases in the coordinate regulation of cell growth: in Mond JJ, Cambier JC, Weiss A (eds): Regulation of Cell Growth and Activation. Advances in Regulation of Cell Growth, New York, Raven Press, 1989, vol. 1, pp. 173–202.
Williams AF, Barclay NA: The immunoglobulin superfamily—Domains for cell surface recognition. Annu Rev Immunol 1988;6:381–405.
Dayhoff M, Schwartz RM, Orcutt BC: A model of evolutionary change in proteins; in Dayhoff M (ed): Atlas of Protein Sequence and Structure. Washington, National Biomedical Resarch Foundation, 1978, vol. 5. suppl 3, pp 345–352.
Devereux J, Haeberli P, Smithies O: A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res 1984;12:387–395.
Smith TF, Waterman MS: Comparison of biosequences. Adv Appl Math 1981;2:482–489.
Pearson WR: Rapid and sensitive sequence comparison with FASTP and FASTA; in Doolittle RF (ed): Molecular Evolution: Computer Analysis of Protein and Nucleic Acid Sequences. Methods in Enzymol. San Diego, Academic Press, 1990, vol. 183, pp 63–98.
Doolittle RF: Scarching through sequence databases; in Doolittle RF (ed): Molecular Evolution: Computer Analysis of Protein and Nucleic Acid Sequences. Methods in Enzymol. San Diego, Academic Press, 1990, vol. 183, pp 99–110.
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Litwin, V., Grose, C. Herpesviral Fc receptors and their relationship to the human Fc receptors. Immunol Res 11, 226–238 (1992). https://doi.org/10.1007/BF02919129
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DOI: https://doi.org/10.1007/BF02919129