Abstract
Carcinogenic chromium(VI), iron(III) nitrilotriacetate, cobalt(II), and nickel(II) react with hydrogen peroxide leading to the production of active species including hydroxyl radical and singlet oxygen, which cause DNA damage.
Similar content being viewed by others
References
E. C. Miller and J. A. Miller,Cancer 47, 1055 (1981).
R. Zimmerman, and P. Cerutti,Proc. Natl. Acad. Sci. USA 81, 2085 (1984).
W. Troll and R. Wiesner,Ann. Rev. Pharmacol. Toxicol.,25, 509 (1985).
G. Kazantzis,Environ. Health Perspect.,40, 143 (1981).
F. W. Sunderman, Jr.,Fed. Proc. 37, 40 (1978).
S. H. Robinson, O. Cantoni, and M. Costa,Carcinogenesis,3, 657 (1982).
M. J. Tsapakos, T. H. Hampton, and K. E. Wetterhahn,Cancer Res.,48, 5662 (1983).
R. B. Ciccarelli and K. E. Wetterhahn,Cancer Res. 42, 3544 (1982).
S. R. Patierno and M. Costa,Chem.-Biol. Interactions 55, 75 (1985).
Y. Ebina, S. Okada, S. Hamazaki, F. Ogino, J. Li, and O. Midorikawa,J. Natl. Cancer Inst. 76, 107 (1986).
S. Inoue and S. Kawanishi,Cancer Res. 47, 6522 (1987).
S. Kawanishi, S. Inoue, and S. Sano,J. Biol. Chem. 261, 5952 (1986).
S. Kawanishi, S. Inoue, S. Sano, and H. Aiba,J. Biol. Chem.,261, 6090 (1986).
K. Yamamoto, S. Inoue, A. Yamazaki, T. Yoshinaga, and S. Kawanishi, under submission.
A. V. Peskin and L. Shlyahova,FEBS Lett. 194, 317 (1986).
J. A. Imlay and S. Linn,Science 240, 1302 (1988).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kawanishi, S., Inoue, S. & Yamamoto, K. Hydroxyl radical and singlet oxygen production and DNA damage induced by carcinogenic metal compounds and hydrogen peroxide. Biol Trace Elem Res 21, 367–372 (1989). https://doi.org/10.1007/BF02917277
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02917277