Abstract
Wistar male rats were exposed to nickel oxide (NiO) aerosols (mass median aerodynamic diameter, 1.2 μm). The average exposure concentration was controlled from low level (0.6 mg/m3) to high level (8.0 mg/m3) and total exposure time ranged from 140 to 216 h. Some rats were sacrificed just after the exposure, whereas others were exposed for 1 mo and kept for a 1-yr clearance period before sacrifice.
There were no differences in body weight gain between NiO exposure groups and controls.
Nickel concentrations in lungs of exposure groups were much higher than those of controls. No apparent deposition of nickel was observed in liver, kidney, spleen, heart, brain, and blood, but lung burdens of up to about 2.35 mg of NiO were found. The apparent deposition fractions were 19.8 and 14.5% after the exposure to average concentrations of 1.4 and 6.5–7.0 mg/m3, respectively.
The clearance rate of NiO deposited in lungs may be small.
Similar content being viewed by others
References
ACGIH, in Threshold Limit Values for Chemical Substances and Physical Agents in the Workroom Environment with Intended Changes for 1983, Publications Office ACGIH, Cincinnati, Ohio, 1983, p. 27.
NIOSH, in HEN publication No. 77-164 US Goyernment Printing Office, Washington DC, 1977, p. 23.
R. Saracci, inQuantification of Occupational Cancer (Banbury report 9,) Cold Spring Harbor Laboratory, 1981, p. 165.
J. D. Bridge, in Annual Report of the Chief Inspector of Factories for the Year 1932, H. M. Stationery Office, London, 1933, pp. 103–104.
F. W. Sunderman, Jr.,Fed. Proc. 37, 40 (1978).
R. Doll, J. D. Mathews, and L. G. Morgan,Br. J. Ind. Med. 34, 102 (1977).
Y. Kodama and N. Ishinishi,J. UOEH 2, 99 (1980).
S. S. Brown and F. W. Sunderman, J.., eds., inNickel Toxicology, Academic Press, New York, 1980, p. 193.
P. Chamner, A. Johansson, and M. Lundborg,Environ. Res. 16, 226 (1978).
M. C. Bruce, P. Chamner, and T. Crustedt, inPulmonary Toxicology of Respirable Particles, C. L. Sanders et al., eds., Technical Information Center, Washington, DC, 1980, pp. 357–366.
A. Johansson and P. Chamner, inPulmonary Toxicology of Respirable Particles, C. L. Sanders et al., eds., Technical Information Center, Washington, DC, 1980, pp. 311–324.
A. Johansson, P. Chamner, and B. Robertson,Environ. Res. 25, 391 (1981).
E. Bingham, W. Barkley, M. Zerwas, K. Stemner, and P. Taylor,Arch. Environ. Health 25, 406 (1972).
A. P. Wehner, O. R. Moss, E. M. Milliman, G. E. Dagle, and R. E. Schirmer,Environ. Res. 19, 355 (1979).
I. Tanaka, H. Hayashi, A. Horie, Y. Kodama, T. Akiyama, and K. Tuchiya,J. UOEH 4, 441 (1982).
A. C. Guyton,Am. J. Physiol. 150, 70 (1947).
O. G. Raabe, W. S. Tyler, J. A. Last, L. W. Schwarts, L. O. Lollini, G. L. Fisher, F. D. Wilson, and D. L. Dungworth,Ann. Occup. Hyg. 26, 189 (1982).
I. Tanaka, K. Matsuno, Y. Kodama, and T. Akiyama,J. UOEH 5, 423 (1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kodama, Y., Ishimatsu, S., Matsuno, K. et al. Pulmonary deposition and clearance of a nickel oxide aerosol by inhalation. Biol Trace Elem Res 7, 1–9 (1985). https://doi.org/10.1007/BF02916542
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02916542