Skip to main content
SpringerLink
Log in

Primary gastric lymphoma is rarely associated with Epstein-Barr virus

  • Original Articles
  • Published:
Virchows Archiv B

Summary

Recently, the association of Epstein-Barr virus (EBV) with undifferentiated lymphoepithelioma-like carcinoma and adenocarcinoma of the stomach has been described. In this study of 55 primary gastric lymphomas, most of them belonging to the group of MALT lymphomas, the question of possible EBV involvement has been addressed using in-situ hybridization (ISH) and blot techniques.

EBV DNA and/or DNA sequences were found in only two of 24 centroblastic and B-immunoblastic lymphomas and in one anaplastic large cell lymphoma of null cell phenotype. In a further centroblastic lymphoma, a few positive nontumorous (bystander) cells were identified by ISH.

By means of ISH, no positive signals could be detected in the preserved overlying mucosa nor in regenerating epithelium adjacent to lymphoma-induced ulcerations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Cogliatti SB, Schmid U, Schumacher U, Eckert F, Hansmann ML, Hedderich J, Takahashi H, Lennert K (1991) Primary B-cell gastric lymphoma: A clinicopathologic study of 145 patients. Gastroenterology 101:1159–1170

    PubMed  CAS  Google Scholar 

  • Dubeau L, Weinberg K, Jones PA, Nichols PW (1988) Studies on immunoglobulin gene rearrangements in formalin-fixed, paraffin-embedded pathology specimens. Am J Pathol 130:588–594

    PubMed  CAS  Google Scholar 

  • Epstein MA, Achong GB, Barr YM (1964) Virus particles in cultured lymphoblasts from Burkitt's lymphoma. Lancet I:702–703

    Article  Google Scholar 

  • Evans AT, Guthrie W (1991) Lymphoepithelioma-like carcinoma of the uvula and the soft palate: a rare lesion in an unusual site. Histopathology 19:184–186

    Article  PubMed  CAS  Google Scholar 

  • Fingeroth JD, Weiss JJ, Tedder RF, Strominger JL, Biro PA, Fearon DT (1984) Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc Natl Acad Sci USA 81:4510–4514

    Article  PubMed  CAS  Google Scholar 

  • Gal AA, Unger ER, Koss MN, Yen TS (1991) Detection of Epstein-Barr virus in lymphoepithelioma-like carcinoma of the lung. Mod Pathol 4:264–268

    PubMed  CAS  Google Scholar 

  • Goelz SE, Hamilton SR, Vogelstein B (1985) Purification of DNA from formaldehyde fixed and paraffin embedded human tissue. Biochem Biophys Res Commun 130:118–126

    Article  PubMed  CAS  Google Scholar 

  • Hamilton-Dutoit SJ, Pallesen G, Franzmann MB, Karkov J, Black F, Skinhoj P, Pedersen C (1991) AIDS-related lymphoma. Histopathology, immunophenotype, and association with Epstein-Barr virus as demonstrated by in situ nucleic acid hybridization. Am J Pathol 138:149–163

    PubMed  CAS  Google Scholar 

  • Hamilton-Dutoit SJ, Pallesen G (1992) A survey of Epstein-Barr virus gene expression in sporadic non-Hodgkin's lymphomas. Detection of Epstein-Barr virus in a subset of peripheral T-cell lymphomas. Am J Pathol 140:1315–1325

    PubMed  CAS  Google Scholar 

  • Herbst H, Dallenbach F, Hummel M, Niedobitek G, Rowe M, Young LS, Müller-Lantzsch N, Stein H (1991) Epstein-Barr virus DNA and latent gene products in CD30-positive anaplastic large cell lymphomas. Blood 78:2666–2671

    PubMed  CAS  Google Scholar 

  • Ho FCS, Srivastava G, Loke SL, Fu KH, Leung BPY, Liang R, Choy D (1990) Presence of Epstein-Barr virus DNA in nasal lymphomas of B- and T-cell type. Hematol Oncol 8, 271–286

    Article  PubMed  CAS  Google Scholar 

  • Howe JG, Steitz JA (1986) Localization of Epstein-Barr virus encoded small RNAs by in situ hybridization. Proc Natl Acad Sci USA 83:9006–9010

    Article  PubMed  CAS  Google Scholar 

  • Isaacson PG, Wright DH (1983) Malignant lymphoma of mucosa-associated lymphoid tissue. A distinvtive type of B-cell lymphoma. Cancer 52:1410–1416

    Article  PubMed  CAS  Google Scholar 

  • Isaacson PG, Spencer J (1987) Malignant lymphoma of mucosa associated lymphoid tissue. Histopathology 11:445–462

    Article  PubMed  CAS  Google Scholar 

  • Jones JF, Shurin S, Abramowsky C, Tubbs RR, Sciotto GS, Wahl R, Sands J, Gottman D, Katz BZ, Sklar J (1988) T-cell lymphomas containing Epstein-Barr virus DNA in patients with chronic Epstein-Barr virus infections. N Engl J Med 318:733–741

    PubMed  CAS  Google Scholar 

  • Klein G, Klein W (1985) Evolution of tumours and the impact of molecular oncology. Nature 315:190–195

    Article  PubMed  CAS  Google Scholar 

  • List AF, Greco A, Vogler LB (1987) Lymphoproliferative diseases in immunocompromised hosts: the role of the Epstein-Barr virus. J Clin Oncol 5:1673–1689

    PubMed  CAS  Google Scholar 

  • Ott G, Ott MM, Feller AC, Seidl S, Müller-Hermelink HK (1992) Prevalence of Epstein-Barr virus DNA in different T-cell lymphoma entities in a European population. Int J Cancer 51:562–567

    Article  PubMed  CAS  Google Scholar 

  • Raab-Traub N, Flynn K (1986) The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation. Cell 47:883–889

    Article  PubMed  CAS  Google Scholar 

  • Radzun HJ, Hansmann ML, Heidebrecht HJ, Bödewadt-Radzun S, Wacker HH, Kreipe H, Lumbeck H, Hernandez C, Kuhn C, Parwaresch MR (1991) Detection of a monocyte/macrophage differentiation antigen in routinely processed paraffinembedded tissues by monoclonal antibody Ki-M1P. Lab Invest 65:306–315

    PubMed  CAS  Google Scholar 

  • Rowe M, Evans H, Young L, Hennessy K, Kieff E, Rickinson AB (1987) Monoclonal antibodies to the latent membrane protein of Epstein-Barr virus reveal heterogeneity of the protein and inducible expression in virus-transformed genes. J Gen Virol 68:1575–1586

    Article  PubMed  CAS  Google Scholar 

  • Shibata D, Tokunaga M, Uemura Y, Sato E, Tanaka S, Weiss LM (1991) Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration. Am J Pathol 139:469–474

    PubMed  CAS  Google Scholar 

  • Shibata D, Weiss LM (1992) Epstein-Barr virus-associated gastric adenocarcinoma. Am J Pathol 140:769–774

    PubMed  CAS  Google Scholar 

  • Shore A, Dosch HM, Gelfand EW (1979) Expression and modulation of C3 receptors during early T cell ontogeny. Cell Immunol 45:157–166

    Article  PubMed  CAS  Google Scholar 

  • Sixbey JW, Nedrud JG, Raab-Traub N, Hanes RA, Pagano JS (1984) Epstein-Barr virus replication in oropharyngeal epithelial cells. N Engl J Med 310:1225–1230

    PubMed  CAS  Google Scholar 

  • Staal SP, Armbinder R, Beschorner WE, Hayward GS, Mann R (1989) A survey of Epstein-Barr virus DNA in lymphoid tissue. Frequent detection in Hodgkin's disease. Am J Clin Pathol 91:1–5

    PubMed  CAS  Google Scholar 

  • Su IJ, Hsieh HC, Lin KH, Uen WC, Kao CL, Chen CJ, Cheng AL, Kadin ME, Chen JY (1991) Aggressive peripheral T-cell lymphomas containing Epstein-Barr viral DNA: a clinicopathological and molecular genetic study. Blood 77:799–808

    PubMed  CAS  Google Scholar 

  • Weiss LM, Strickler JG, Warnke RA, Purtilo DT, Sklar J (1987) Epstein-Barr viral DNA in tissues of Hodgkin's disease. Am J Pathol 129:86–91

    PubMed  CAS  Google Scholar 

  • Weiss LM, Gaffey MJ, Chen YY, Frierson HF (1992) Frequency of Epstein-Barr viral DNA in “Western” sinonasal and Waldeyer's ring non-Hodgkin's lymphomas. Am J Surg Pathol 16:156–162

    Article  PubMed  CAS  Google Scholar 

  • Young LS, Clark D, Sixbey JW, Rickinson AB (1986) Epstein Barr virus receptors on human pharyngeal epithelia. Lancet I:240–242

    Article  Google Scholar 

  • Zur Hausen H, Schulte-Holthausen H, Klein G, Henle W, Henle G, Clifford P, Santesson L (1970) EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx. Nature 228:1056

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Pathology, University of Würzburg, Josef-Schneider-Strasse 2, D-97080, Würzburg, Germany

    G. Ott, Th Kirchner, S. Seidl & H. K. Müller-Hermelink

Authors
  1. G. Ott
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Th Kirchner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Seidl
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. K. Müller-Hermelink
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This study was supported by the Deutsche Forschungsgemeinschaft, Sonderforschungsbereich 172, C8.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ott, G., Kirchner, T., Seidl, S. et al. Primary gastric lymphoma is rarely associated with Epstein-Barr virus. Virchows Archiv B Cell Pathol 64, 287–291 (1993). https://doi.org/10.1007/BF02915124

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02915124

Key words

Search

Navigation