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Hemolysis after mitral valve replacement with mechanical valve prostheses

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Abstract

Objective: We evaluated effects of type, size, and orientation of mechanical mitral valve prostheses on hemolysis.Methods: Subjects were 84 patients who had undergone mitral valve replacement. Lactate dehydrogenase was mainly used as a marker of hemolysis and was measured before surgery, 1 month after surgery, and in the late postoperative period.Results: Valves used included 16 Medtronic-Hall, 32 St. Jude Medical, and 36 CarboMedics valves. Medtronic-Hall valves caused less hemolysis than St. Jude Medical or CarboMedics valves in the late postoperative period. This resulted because hemolysis due to Medtronic-Hall valves was more severe 1 month after surgery than in the late postoperative period and because hemolysis due to St. Jude Medical or CarboMedics valves was more severe in the late postoperative period than 1 month after surgery. One reason for this finding is that cardiac output was greater in the late postoperative period than 1 month after surgery, making regurgitation through the pivots of bileaflet valves more severe. The orifice area and the orientation of prostheses did not affect hemolysis.Conclusion: St. Jude Medical or CarboMedics valves caused more severe hemolysis than Medtronic-Hall valves in the late postoperative period.

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Authors and Affiliations

  1. Department of Cardiothoracic Surgery, Faculty of Medicine, University of Tokyo, 6-15-13-9 Hon-Komagome, Bunkyo-ku, 113-01, Tokyo, Japan

    Mikio Ninomiya, Yukihiro Kaneko, Yutaka Kotsuka & Shinichi Takamoto

  2. Department of Cardiovascular Surgery, Japanese Red Cross Medical Center, Tokyo, Japan

    Kuniyoshi Yagyu

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  1. Mikio Ninomiya
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  2. Kuniyoshi Yagyu
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  3. Yukihiro Kaneko
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  4. Yutaka Kotsuka
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  5. Shinichi Takamoto
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Ninomiya, M., Yagyu, K., Kaneko, Y. et al. Hemolysis after mitral valve replacement with mechanical valve prostheses. Jpn J Thorac Cardiovasc Surg 49, 230–235 (2001). https://doi.org/10.1007/BF02913521

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  • DOI: https://doi.org/10.1007/BF02913521

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