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Ets-1 gene expression in patients with thymoma

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Abstract

Objectives: The Ets-1 protooncogene transcription factor is involved in several cellular functions, including the activation of several proteases, and reportedly plays an important role in carcinoma invasion and metastasis. We hypothesize that Ets-1 mRNA expression could be a predictor of thymoma development and invasion.Methods: Subjects were 37 patients with thymoma whose mRNA expression was quantified by realtime reverse-transcription polymerase chain reaction (RT-PCR) using Light Cycler, a microvolume multisample fluorimeter.Results: No significant difference was found in Ets-1 mRNA expression for gender, age, or pathological subtype. Ets-1 mRNA expression in tumor tissues from stage II–IV thymoma (25.311±42.336) was more elevated than in that from stage I thymoma (2.097±4.492) (p=0.0374). Ets-1 mRNA expression may thus serve as a marker of higher thymoma stages.Conclusions: With use of the Light Cycler RT-PCR assay, Ets-1 expression may play an important role in the extension and progression of thymoma as in other cancers. Further study and longer follow-up are, however, needed to confirm the Ets-1 impact on biological tumor behavior.

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Authors and Affiliations

  1. Department of Surgery II, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan

    Hidefumi Sasaki MD, Yoshihiro Kobayashi MD, Masayuki Tanahashi MD, Haruhiro Yukiue MD, Motoki Yano MD, Masahiro Kaji MD, Masanobu Kiriyama MD, Ichiro Fukai MD, Yosuke Yamakawa MD & Yoshitaka Fujii MD

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  1. Hidefumi Sasaki MD
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  2. Yoshihiro Kobayashi MD
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  3. Masayuki Tanahashi MD
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  4. Haruhiro Yukiue MD
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  5. Motoki Yano MD
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  6. Masahiro Kaji MD
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  7. Masanobu Kiriyama MD
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  8. Ichiro Fukai MD
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  9. Yosuke Yamakawa MD
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  10. Yoshitaka Fujii MD
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Sasaki, H., Kobayashi, Y., Tanahashi, M. et al. Ets-1 gene expression in patients with thymoma. Jpn J Thorac Cardiovasc Surg 50, 503–507 (2002). https://doi.org/10.1007/BF02913162

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  • DOI: https://doi.org/10.1007/BF02913162

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