Abstract
The present study was undertaken to explore the relationship of plasma homocysteine with other biochemical parameters in ischemic heart disease. Plasma levels of total homocysteine was measured by HPLC—fluorescence detection with internal standard in 60 ischemic heart disease patients and were compared with 30 age matched normal healthy controls. The significant increase of plasma homocysteine was observed in both myocardial infarction and chronic stable ischemic heart disease patients when compared with the controls. The hyperhomocysteinemia appears be to due to increased body demand of vitamins such as folic acid, vitamin B12, B6, B2 either alone or in combination to regulate normal homocysteine metabolism.
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Graham, I.M., Daly, L.E. and Refsum, H.M. (1997) Plasma homocysteine as risk factor for vascular disease. The European Concerted Action Project. J. Am. Med. Assocn. 277, 1775–1781.
Wald, N.J., Walt, H.C., Law, M.R., Weir, D.G., Mc Partlin, J. and Scott, J.M. (1998) Homocysteine and ischemic heart disease. Arch. Int. Med. 158, 862–867.
Sathia, G. and Lalitha, S. (2000) Homocysteine and cardiovascular disease. Ind. J. Clin. Practice, 11/6, 59–65.
Welch, G. and Loscalzo, J. (1998) Homocysteine and atherothrombosis. N. Eng. J. Med. 338/15, 1042–1050.
Chambers, J.C., Obeid, O.A. and Refsum, H. (2000) Plasma homocysteine concentrations and risk of coronary heart disease in UK, Indian Asians and European men. Lancet 355, 523–527.
Singh, M. (2000) A case of acute myocardial infarction associated with hyperhomocysteinemia. J. Ind. Acad. Clin. Med. 3/3, 317–318.
Ueland, P., Refsum, H., Stabler, S., Malinow, M., Andresson, A. and Allen, R. (1993) Total homocysteine in plasma or serum: Methods and clinical applications. Clin. Chem. 39/9, 1764–1779.
Schreiner, R., Gobel-Schreiner, B. and Walch, S. (1995) Homocysteine: Biochemie and Klinische Bedeutung. Clinical Laboratory 41, 1007–1011.
Silkers, K.A. and Crit, C.R.C. (1997) Estimation of serum total cholesterol by enzymatic method. Rev. Clin. Lab. Sci. 8, 198.
Richmond, W. (1973) Estimation of serum HDL-cholesterol. Clin. Chem. 19, 1350.
Buccola, G. and David, M. (1973) Estimation of serum triglycerides. Clin. Chem. 19, 476.
Mc Neely, M.D. (1987) Folic acid. In: Presce, A.J., Kaplan, L.A., editors, Methods in clinical laboratory, St. Louis: CV Mosby, Page No. 539–542.
Chen, J.W., Sperling, M.I. and Heminger, L.A. (1987) Vitamin B12 In: Presce, A.J., Kaplan, L.A., editors, Methods in clinical laboratory, St. Louis: CV Mosby, Page No. 569–573
Kei, Satoh (1978) Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clinica. Chimica. Acta. 90, 37–43.
Cholesterol guidelines (2001) A call for more aggressive lipid lowering. Current Medical Scene, 16/3, 1.
Israelsson, B., Brattstrom, L.E. and Hultberg, B.E. (1988) Homocysteine and myocardial infarction. Atherosclerosis 71, 227–233.
De Bree, A., Verschuren, W.M.M., Kromhout, D., Klujtmans, L.A.J. and Blom, H.J. (2002) Homocysteine determinants and the evidence to what extent homocysteine determine the risk of coronary heart disease. Pharmacol. Rev. 54/4, 599–618.
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Yadav, A.S., Bhagwat, V.R. & Rathod, I.M. Relationship of plasma homocysteine with lipid profile parameters in ischemic heart disease. Indian J Clin Biochem 21, 106–110 (2006). https://doi.org/10.1007/BF02913076
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DOI: https://doi.org/10.1007/BF02913076